Spatial regulation and generation of diversity in signaling pathways.
Title | Spatial regulation and generation of diversity in signaling pathways. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Saini N, Sarin A |
Journal | J Biosci |
Volume | 46 |
Date Published | 2021 |
ISSN | 0973-7138 |
Abstract | Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. These interactions, which are played out in micro-environments within cells and involve a relatively small number of core pathways, are the key to the development and function of multi-cellular organisms. How these outcomes are regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. This review specifically addresses spatial positioning of molecules as a means of enabling interactions and novel outcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanisms that contribute to diverse signaling outcomes. |
Alternate Journal | J Biosci |
PubMed ID | 33785678 |