Bridging disciplines. Unifying ideas. 

The Institute for Stem Cell Science and Regenerative Medicine (inStem), is a state-of-the-art research institute in Bangalore, India, dedicated to the study of stem cell and regenerative biology.
An autonomous institute funded by the Dept of Biotechnology, Govt. of India, inStem emphasizes collaborative research in stem cell biology. inStem’s mandate to allow this cross-disciplinary, multi-pronged approach to research, straddles the divide between clinical and laboratory research in stem cell biology. In trying to answer intractable and challenging questions that face the field, inStem seeks to rewrite the paradigm of the research institute: without barriers and across disciplines.

Research at inStem, encompasses a wide range of topics in stem cell biology: from questions about the fundamental mechanisms that control differentiation and renewal, to clinical studies on the impact of stem cells on recovery from stroke/injury. The institute is also home to the Wadhwani Centre, a generous philanthropic donation dedicated to the study of stem cell biology of the nervous system as well as cardiomyopathies. inStem’s fast-growing, young and enthusiastic atmosphere ensures that its work is at the very forefront of science.

Research at inStem is well-supported, with access to facilities at both NCBS and Centre for Cellular and Molecular Platforms (C-CAMP). Together these three institutions serve as part of the Bangalore Biocluster. inStem is also the umbrella organization for three initiatives: inStem itself, the Center for Stem Cell Research (CSCR) located at CMC Vellore, and an Extramural Program in Stem Cell Research (EPiSTEM), a funding initiative for support of stem cell research nationwide. Strategically placed in the biotechnology hub of India with access to world-class research and facilities, inStem is perfectly positioned to take its place as a leader in stem cell biology and regenerative medicine research.

 inStem’s unique ability is that it uses the collective strength of excellent, diverse faculty and world-class facilities to drive thought-provoking investigations on difficult, yet necessary, questions in stem cell biology. One such initiative is the development of an interdisciplinary, international collaboration on cardiac hypertrophy and regeneration. Along with the labs at inStem and NCBS, this is a joint collaboration with labs at Stanford and looks at the physiology and genetics of inherited cardiomyopathies. The investigations span from single molecule biophysical platforms to cardiac physiology in genetically engineered mouse models while using stem cell biology tools in tackling these questions.

Apart from this, inStem has established collaborative programs with iCeMS, Kyoto, Japan, with Cambridge University (chemical biology of cancer), with IFOM, Milan, with Stempeutics (for research in mesenchymal stem cells) and with MacLaughlin Research Institute, Montana USA (to collaborate on generation of mouse models for study of development and disease).
Jointly with CIRM (California Institute of Regenerative medicine, California), inStem funds collaborative projects that seek to understand stem cells and their future role in human disease. For projects under this collaboration, CIRM and inStem invite scientists in India and California to form teams to file a single, fully integrated scientific project proposal. Proposals that pass review in both jurisdictions will have the California researchers funded by CIRM and the Indian researchers funded by inStem.

In a major boost to research at inStem, the Shanta Wadhwani Centre at inStem was established by a single philanthropic grant by the Wadhwani foundation. The Centre’s broad goal is to support research aimed at understanding the role of stem cells in neuroscience and cardiomyopathies. Emphasizing these two goals, the Centre funds studies at the cellular and molecular level that examine neuronal and cardiac regenerative mechanisms. In addition, the Centre has programs supporting entrepreneurs and research by the disabled.

Research at inStem is well-supported with access to the state-of-the-art facilities at both NCBS and Centre for Cellular and Molecular Platforms (C-CAMP). C-CAMP provides tools for genomics, proteomics, next-generation sequencing and other facilities to inStem researchers allowing rapid progress in data generation and analysis. C-CAMP also manages inStem’s interface with industry.

inStem’s vibrant, enthusiastic and intellectual environment and its committed faculty provide a great environment for educational and training programs. Currently, programs exist to support postdocs, graduate students and project trainees. A key focus will be on the creation of a supportive environment for outstanding young investigators through a Fellows Program. In addition to didactic and practical courses for PhD level training, which will be developed jointly with CSCR and NCBS, inStem will hold workshops and conferences on frontier areas in stem cell research and applications.

inStem will develop and manage a web-based outreach program to provide the public with access to information on current stem cell research world-wide.