@article {2243,
	title = {Spatial regulation and generation of diversity in signaling pathways.},
	journal = {J Biosci},
	volume = {46},
	year = {2021},
	month = {2021},
	abstract = {<p>Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. These interactions, which are played out in micro-environments within cells and involve a relatively small number of core pathways, are the key to the development and function of multi-cellular organisms. How these outcomes are regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. This review specifically addresses spatial positioning of molecules as a means of enabling interactions and novel outcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanisms that contribute to diverse signaling outcomes.</p>
},
	issn = {0973-7138},
	author = {Saini, Neetu and Sarin, Apurva}
}
