TitleMicroneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare.
Publication TypeJournal Article
Year of Publication2021
AuthorsPahal S, Badnikar K, Ghate V, Bhutani U, Nayak MManjunatha, Subramanyam DNarasimhai, Vemula PKumar
JournalEur J Pharm Biopharm
Date Published2021 Feb

Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation.

Alternate JournalEur J Pharm Biopharm
PubMed ID33388372