Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare.
Title | Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Pahal S, Badnikar K, Ghate V, Bhutani U, Nayak MManjunatha, Subramanyam DNarasimhai, Vemula PKumar |
Journal | Eur J Pharm Biopharm |
Volume | 159 |
Pagination | 151-169 |
Date Published | 2021 Feb |
ISSN | 1873-3441 |
Abstract | Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation. |
DOI | 10.1016/j.ejpb.2020.12.020 |
Alternate Journal | Eur J Pharm Biopharm |
PubMed ID | 33388372 |