%0 Journal Article %J Eur J Pharm Biopharm %D 2021 %T Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare. %A Pahal, Suman %A Badnikar, Kedar %A Ghate, Vivek %A Bhutani, Utkarsh %A Nayak, Mangalore Manjunatha %A Subramanyam, Dinesh Narasimhaiah %A Vemula, Praveen Kumar %X

Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation.

%B Eur J Pharm Biopharm %V 159 %P 151-169 %8 2021 Feb %G eng %R 10.1016/j.ejpb.2020.12.020