Characterization of new variant human ES line VH9 hESC (INSTEMe001-a): a tool for human stem cell and cancer research.
| Title | Characterization of new variant human ES line VH9 hESC (INSTEMe001-a): a tool for human stem cell and cancer research. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Arasala RRao, Jayaram M, Chattai J, Kumarasamy T, Sambasivan R, Rampalli S |
| Journal | Stem Cell Res |
| Volume | 37 |
| Pagination | 101444 |
| Date Published | 2019 May |
| ISSN | 1876-7753 |
| Abstract | Human pluripotent stem cells (hPSCs) acquire changes at the genomic level upon proliferation and differentiation (Peterson and Loring, 2014). Studies from International Stem Cell Initiative and independent laboratories identified a copy number variant (CNV) in hES cell lines displaying a normal karyotype, which provided a selective advantage to hES cells in culture. In our laboratory we have identified variant H9-hESC (derived from H9-hESC) with normal karyotype, pluripotency expression, differentiation profile but with altered traits of high cell survival and low E-CADHERIN expression. |
| DOI | 10.1016/j.scr.2019.101444 |
| Alternate Journal | Stem Cell Res |
| PubMed ID | 31075691 |