TY - JOUR T1 - Characterization of new variant human ES line VH9 hESC (INSTEMe001-a): a tool for human stem cell and cancer research. JF - Stem Cell Res Y1 - 2019 A1 - Arasala, Radhika Rao A1 - Jayaram, Manjunath A1 - Chattai, Jagamohan A1 - Kumarasamy, Thangaraj A1 - Sambasivan, Ramkumar A1 - Rampalli, Shravanti AB -

Human pluripotent stem cells (hPSCs) acquire changes at the genomic level upon proliferation and differentiation (Peterson and Loring, 2014). Studies from International Stem Cell Initiative and independent laboratories identified a copy number variant (CNV) in hES cell lines displaying a normal karyotype, which provided a selective advantage to hES cells in culture. In our laboratory we have identified variant H9-hESC (derived from H9-hESC) with normal karyotype, pluripotency expression, differentiation profile but with altered traits of high cell survival and low E-CADHERIN expression.

VL - 37 ER -