1. SENIOR SCIENTIST – HIGH THROUGHPUT SCREENING AUTOMATION

• KNOWLEDGE, EXPERIENCE AND SKILLS

• PhD, in Molecular Biology/Cell Biology/Biochemistry

• Minimum 3-5 yrs of industry experience beyond PhD in assay design, execution, and high-throughput screening

• Previous experience using liquid handling stations, implementing high content screens, automated microscopy and handling large data sets are encouraged to apply

• Experience in areas such as chromatin regulation, cell cycle and cell signaling is desirable

• JOB DESCRIPTION

• In this position you will support chemical biology efforts underpinning new lead discovery by providing high throughput biology expertise including, but not limited to the following;

• Develop, optimize and validate biological assays amenable to automation and high throughput screening

• Automate high throughput screening assays to support lead discovery programs.

• Perform primary high throughput screening, secondary hit profiling assays, and focused small molecule screens

• Program and operate custom-integrated automation systems, prepare assay reagents and execute assays

• Perform data analysis, reporting and integration with database software

• Interact with multidisciplinary project teams for lead discovery

• Participate in project team meeting and contribute to the projects intellectually and communicate data

• DUTIES AND JOB FUNCTIONS

• Specific experience with high throughput screening and assay development Experience in biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP, alpha screen, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies.

• Solid understanding of modern high throughput screening assay technologies

• Specific experience using laboratory automation equipment

• Excellent computer skills with experience in data analysis

• Must be detail oriented, well organized, and have strong communication skills

• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

• Managerial experience of junior scientists

2. HIGH THROUGHPUT SCREENING TECHNOLOGY ASSOCIATE

• KNOWLEDGE, EXPERIENCE AND SKILLS

• Master's degree in discipline of life sciences B.Tech in Bio-Technology with 1-3 years of work experience

• Substantial experience with high throughput screening of enzyme/cell-based assay using small molecule libraries is essential.

• JOB DESCRIPTION

• Support chemical biology efforts underpinning new lead discovery efforts by providing high throughput biology expertise including, but not limited to the following;

• Proficient in biochemistry, enzymology, assay development, lab automation and HTS

• High throughput screening assays and application of various in vitro techniques

• Specific experience with biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP and alpha screen assays

• HTS sample processing, data generation, data interpretation and data reporting

• Responsible for conducting in vitro animal cell culture, etc. as and when required

• Assist in maintenance of HTS compound/sample libraries, laboratory administrative requirements and maintenance of good laboratory practices in work environment

• DUTIES AND JOB FUNCTIONS

• Understanding of modern high throughput screening assay technologies

• Experience in using laboratory automation equipment

• Computer skills with experience in data analysis

• Must be detail oriented, well organized, and have strong communication skills

• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

HOW TO APPLY: Interested candidates may send in the following information by email to jobs-ccbt@instem.res.in

• Curriculum Vitae (CV)
• Publication list
• Contact details of three professional referees
• Specify "High Throughput Screening" and your designation in the subject line of your email