Anti-cancer Activity of Biogenic Nat-ZnO Nanoparticles Synthesized Using Nyctanthes arbor-tristis (Nat) Flower Extract.
Title | Anti-cancer Activity of Biogenic Nat-ZnO Nanoparticles Synthesized Using Nyctanthes arbor-tristis (Nat) Flower Extract. |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Chabattula SChander, Gupta PKumar, Govarthanan K, Varadaraj S, Rayala SKumar, Chakraborty D, Verma RShanker |
Journal | Appl Biochem Biotechnol |
Volume | 196 |
Issue | 1 |
Pagination | 382-399 |
Date Published | 2024 Jan |
ISSN | 1559-0291 |
Keywords | Animals, Anti-Bacterial Agents, Flowers, Metal Nanoparticles, Mice, Microbial Sensitivity Tests, nanoparticles, Plant Extracts, Zinc Oxide |
Abstract | Inorganic nanoparticles (NPs) have played an important role as nano-drug delivery systems during cancer therapy in recent years. These NPs can carry cancer therapeutic agents. Due to this, they are considered a promising ancillary to traditional cancer therapies. Among inorganic NPs, Zinc Oxide (ZnO) NPs have been extensively utilized in cellular imaging, gene/drug delivery, anti-microbial, and anti-cancerous applications. In this study, a rapid and cost-effective method was used to synthesize Nat-ZnO NPs using the floral extract of the Nyctanthes arbor-tristis (Nat) plant. Nat-ZnO NPs were physicochemically characterized and tested further on in vitro cancer models. The average hydrodynamic diameter (Z) and the net surface charge of Nat-ZnO NPs were 372.5 ± 70.38 d.nm and -7.03 ± 0.55 mV, respectively. Nat-ZnO NPs exhibited a crystalline nature. HR-TEM analysis showed the triangular shape of NPs. Furthermore, Nat-ZnO NPs were also found to be biocompatible and hemocompatible when tested on mouse fibroblast cells and RBCs. Later, the anti-cancer activity of Nat-ZnO NPs was tested on lung and cervical cancer cells. These NPs displayed potent anti-cancer activity and induced programmed cell death in cancer cells. |
DOI | 10.1007/s12010-023-04555-1 |
Alternate Journal | Appl Biochem Biotechnol |
PubMed ID | 37133677 |
PubMed Central ID | 2962271 |