Chemical journey of somatic cells to pluripotency.
| Title | Chemical journey of somatic cells to pluripotency. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Abbey D |
| Journal | Cell Regen |
| Volume | 11 |
| Issue | 1 |
| Pagination | 27 |
| Date Published | 2022 Aug 03 |
| ISSN | 2045-9769 |
| Abstract | Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using a small molecule cocktail of epigenetic modifiers and cell signalling inhibitors, a chemical-based easy and controllable technique for converting human somatic cells into chemically induced pluripotent stem cells was recently reported (Guan, Nature 605:325-31, 2022). This novel approach offers well-defined, safe, simple, easy, and clinical-grade manufacturing strategies for modifying the fate of human cells required for regenerative therapeutics. |
| DOI | 10.1186/s13619-022-00126-7 |
| Alternate Journal | Cell Regen |
| PubMed ID | 35918563 |
| PubMed Central ID | PMC9346013 |