• Giulia I. Corsi, Veerendra P. Gadekar, Henriette Haukedal, Nadezhda T. Doncheva, Christian Anthon, S. Ambardar, Dasaradhi Palakodeti, P. Hyttel, K. Freude, S. Seemann, J. Gorodkin. The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression.  Neurobiology of Disease (December 2022) (DOI: 10.1016/j.nbd.2022.105980).

 

  • Vinay Kumar Dubey, Souradeep R. Sarkar, Vairavan Lakshmanan, Rimple Dalmeida, A. Gulyani, Dasaradhi Palakodeti*. Smed-ETS-1 regulates cathepsin+ cell function and epidermal lineage landscape via basement membrane remodeling. Journal of cell science (September 2022) (*Corresponding author) (DOI: 10.1242/jcs.259900).

 

  • Souradeep R. Sarkar, Vinay Kumar Dubey, Anusha Jahagirdar, Vairavan Lakshmanan, M. Haroon, S. Sowndarya, R. Sowdhamini, Dasaradhi Palakodeti*. DDX24 is required for muscle fiber organization and the suppression of wound-induced Wnt activity necessary for pole re-establishment during planarian regeneration. Developmental biology (May 2022) (*Corrosponding author) (DOI: 10.1016/j.ydbio.2022.04.011). 

 

  • Nivedita Hariharan, Sumana Ghosh, Dasaradhi Palakodeti*. The story of rRNA expansion segments: Finding functionality amidst diversity.  Wiley Interdisciplinary Reviews: RNA (April 2022) (*Correspondin autor) (DOI: 10.1002/wrna.1732).

 

  • M. Haroon*, P. Vemula*, Dasaradhi Palakodeti*. Flow Cytometry Analysis of Planarian Stem Cells Using DNA and Mitochondrial Dyes. Bio-protocol (2022) (* correspondin authors) (DOI: 10.21769/BioProtoc.4299).

 

  • Pratul Kumar Jain, Shashank Jayappa, T. Sairam, Anupam Mittal, Sayan Paul, Vinay J. Rao, Harshil Chittora, D. Kashyap, Dasaradhi Palakodeti, K. Thangaraj, J. Shenthar, Rakesh Koranchery, Ranjith Rajendran, Haghighi Alireza, K. Mohanan, A. Rathinavel, Perundurai S. Dhandapany. Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy. Biology, Medicine (December 2021) (DOI: 10.1136/jmedgenet-2021-107866).

 

  • Michelle Ninochka D’Souza, Sarayu Ramakrishna, B. K. Radhakrishna, Vishwaja Jhaveri, Sreenath Ravindran, Lahari Yeramala, Dasaradhi Palakodeti, Ravi S Muddashetty. Function of FMRP domains in regulating distinct roles of neuronal protein synthesis. Molecular Neurobiology (October 2022) (DOI: 10.1007/s12035-022-03049-1). 

 

  • Sameena Nikhat, A. D. Yadavalli, Arpita Prusty, Priyanka Narayan, Dasaradhi Palakodeti, C. Murre, J. Pongubala. A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes. Proceedings of the National Academy of Science ( November 2021) ( DOI: 10.1073/pnas.2104297118).

 

  • Oindrila Bhattacharjee, Uttkarsh Ayyangar, Ambika S. Kurbet, Vairavan Lakshmanan, Dasaradhi Palakodeti, F. Ginhoux, Srikala Raghavan. Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Frontiers in Immunology (October 2021) ( DOI: 10.3389/fimmu.2021.718005).

 

  • Anirudh Chakravarthy, Anirudh Nandakumar, Geen George, Shyamsundar Ranganathan, Suchitta Umashankar, Nishan Shettigar, Dasaradhi Palakodeti, A. Gulyani, A. Ramesh . Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay. Life Science Alliance (September 2021) ( DOI: 10.26508/lsa.202101213).

 

  • S. P. Subramanian, Vairavan Lakshmanan, Dasaradhi Palakodeti, R. Subramanian. Glycomic and glycotranscriptomic profiling of mucin-type O-glycans in planarian Schmidtea mediterranea. Glycobiology (September 2021) (DOI:10.1093/glycob/cwab097).

 

  • Nishan Shettigar, Anirudh Chakravarthy, Suchitta Umashankar, Vairavan Lakshmanan, Dasaradhi Palakodeti, A. Gulyani. Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye–brain-independent movement and arousal. Proceedings of the National Academy of Sciences (May 2021) (DOI: 10.1073/pnas.2021426118).

 

  • Srikar Krishna, Srikala Raghavan*, R. Dasgupta*, Dasaradhi Palakodeti*. tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation. Cellular and Molecular Life Sciences (January 2021) (*Correspondin author) (DOI: 10.1007/s00018-020-03720-7). 

 

  • M. Haroon, Vairavan Lakshmanan, Souradeep R. Sarkar, Kai Lei, P. Vemula*, Dasaradhi Palakodeti*. Mitochondrial state determines functionally divergent stem cell population in planaria. Stem cell Reports (May 2021) (*Correspondin author) (DOI: 10.1016/j.stemcr.2021.03.022).

 

  • Alok Javali, Vairavan Lakshmanan, Dasaradhi Palakodeti, R. Sambasivan. Modulation of β‐catenin levels regulates cranial neural crest patterning and dispersal into first pharyngeal arch. Developmental Dynamics ( May 2020) (DOI: 10.1002/dvdy.208). 

 

  •  A. Sarkar, Namita Mukundan, S. Sowndarya, Vinay Dubey, R. Babu, Vairavan Lakshmanan, Kannan Rangiah, M. Panicker, Dasaradhi Palakodeti, S. P. Subramanian, R. Subramanian. Serotonin is essential for eye regeneration in planaria Schmidtea mediterranea. FEBS Letters (November 2019) ( DOI: 10.1002/1873-3468.13607).

 

  • S. Ganesan, Hamenth Kumar Palani, Vairavan Lakshmanan, N. Balasundaram, A. A. Alex, S. David, Arvind Venkatraman, A. Korula, B. George, P. Balasubramanian, Dasaradhi Palakodeti, N. Vyas, V. Mathews. Stromal cells downregulate miR-23a-5p to activate protective autophagy in acute myeloid leukemia. Cell Death and Disease ( September 2019) (Link: https://www.nature.com/articles/s41419-019-1964-8).

 

  • Srikar Krishna, Daniel GR Yim, Vairavan Lakshmanan, Varsha Tirumalai, Judice LY Koh, Jung Eun Park, Jit Kong Cheong, Joo Leng Low, Michelle JS Lim, Siu Kwan Sze, Padubidri Shivaprasad, Akash Gulyani, Srikala Raghavan*, Dasaradhi Palakodeti*, Ramanuj DasGupta*.  Dynamic expression of tRNA‐derived small RNAs define cellular states. EMBO Reports (June 2019) (*corresponding authors) (Link: https://www.embopress.org/doi/10.15252/embr.201947789) 

 

  • Radhika Arasala Rao, Alhad Ashok Ketkar, Neelam Kedia, Vignesh K Krishnamoorthy, Vairavan Lakshmanan, Pankaj Kumar, Abhishek Mohanty, Shilpa Dilip Kumar, Sufi O Raja, Akash Gulyani, Chandra Prakash Chaturvedi, Marjorie Brand, Dasaradhi Palakodeti, Shravanti Rampalli.  KMT1 family methyltransferases regulate heterochromatin–nuclear periphery tethering via histone and non‐histone protein methylation.  EMBO Reports (March 2019)  (Link: https://www.embopress.org/doi/10.15252/embr.201643260)

 

  • Srikar Krishna, Dasaradhi Palakodeti, Jordi Solana. Post-transcriptional regulation in planarian stem cells. Seminars in Cell & Developmental Biology (March 2019).  (Link: https://www.sciencedirect.com/science/article/pii/S1084952117302045) 

 

  • Michelle Ninochka D’Souza, Naveen Kumar Chandappa Gowda, Vishal Tiwari, Rosana Ottakandathil Babu, Praveen Anand, Sudhriti Ghosh Dastidar, Randhir Singh, Owen G. James, Bhuvaneish Selvaraj, Rakhi Pal, Arati Ramesh, Sumantra Chattarji, Siddharthan Chandran, Akash Gulyani, Dasaradhi Palakodeti, and Ravi S. Muddashetty. FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation. iScience (November 2018) (Link: https://www.cell.com/iscience/pdf/S2589-0042(18)30197-4.pdf)

 

  • Kannan Rangiah and Dasaradhi Palakodeti. Quantification of Neurotransmitters from Intact and Regenerating Planarians Using UHPLC-MS/SRM Method. Methods in Molecular Biology (June 2018) (Link: https://link.springer.com/protocol/10.1007%2F978-1-4939-7802-1_25) 

 

  • Sabarinath Peruvemba Subramanian, Ponnusamy Babu, Dasaradhi Palakodeti and Ramaswamy Subramanian. Identification of multiple isomeric core chitobiose–modified high-mannose and paucimannose N-glycans in the planarian Schmidtea mediterranea. Journal of Biological Chemistry (May 2018) (Link: http://www.jbc.org/content/293/18/6707.full.pdf) 

 

  • Sasidharan Vidyanand, Srujan Marepally, Sarah A. Elliott, Srishti Baid, Vairavan Lakshmanan, Nishtha Nayyar, Dhiru Bansal, Alejandro Sánchez Alvarado, Praveen Kumar Vemula, Dasaradhi Palakodeti. The miR-124 family of microRNAs is critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea. Development (September, 2017) (Link: http://dev.biologists.org/content/early/2017/08/11/dev.144758.long)

 

  • Dhiru Bansal, Jahnavi Kulkarni, Kavana Nadahalli, Vairavan Lakshmanan, Srikar Krishna, Vidyanand Sasidharan, Jini Geo , Shilpa Dilipkumar, Renu Pasricha , Akash Gulyani , Srikala Raghavan and Dasaradhi Palakodeti. Cytoplasmic poly (A)-binding protein critically regulates epidermal maintenance and turnover in the planarian Schmidtea mediterranea. Development (August 29, 2017). (Link: http://dev.biologists.org/content/144/17/3066)

 

  • Boya R, Yadavalli AD, Nikhat S, Kurukuti S, Palakodeti D, Pongubala JM. Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment. Nucleic Acids Research (August 17, 2017).  (Link: https://doi.org/10.1093/nar/gkx722)

 

  • Shettigar N, Joshi A,Dalmeida R, Gopalkrishna R, Chakravarthy A, Patnaik S, Mathew M, Palakodeti D*, Gulyani A*. Hierarchies in light sensing and dynamic interactions between ocular and extraocular sensory networks in a flatworm. Science Advances (28 July 2017). (*corresponding authors)       (Link: http://advances.sciencemag.org/content/3/7/e1603025)

 

  • Arya D, Sachithanandan SP, Ross C, Palakodeti D, Li S, Krishna S. miRNA-182 regulates percentage of myeloid and erythroid cells in chronic myeloid leukemia. Cell Death & Disease. 2017 Jan 12;8(1):e2547.

 

  • Lakshmanan V, Bansal D, Kulkarni J, Poduval D, Krishna S, Sasidharan V, Anand P, Seshasayee A, Palakodeti D. Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea. G3 (Bethesda). October, 2016. (http://www.g3journal.org/content/6/10/3035)

 

  • Natarajan N, Ramakrishnan P, Lakshmanan V, Palakodeti D, Rangiah K. A quantitative metabolomics peek into planarian regeneration. Analyst. 2015 May 21;140(10):3445-64.

 

  • Rao RA, Dhele N, Cheemadan S, Ketkar A, Jayandharan GR, Palakodeti D, Rampalli S. Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming. Sci Rep. 2015 Feb 4;5:8229.

 

  • Vyas N, Walvekar A, Tate D, Lakshmanan V, Bansal D, Lo Cicero A, Raposo G, Palakodeti D, Dhawan J. Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties. Sci Rep. 2014 Dec 8;4:7357.

 

  • Rangiah K, Palakodeti D. Comprehensive analysis of neurotransmitters from regenerating planarian extract using an ultrahigh-performance liquid chromatography/mass spectrometry/selected reaction monitoring method. Rapid Commun Mass Spectrom. 2013 Nov 15;27(21):2439-52.

 

  • Sasidharan V, Lu YC, Bansal D, Dasari P, Poduval D, Seshasayee A, Resch AM, Gaveley BR,* Palakodeti D.* Identification of neoblast and regeneration specitic miRNAs in planarian Schmidtea mediterranea. RNA 2013 (*corresponding authors) (http://rnajournal.cshlp.org/content/19/10/1394.long)

 

  • Rangaiah K,* Palakodeti D. Comprehensive analysis of neurotransmitters in regenerating planarian extract using UHPLC-MS/SRM. Rapid Communications in Mass Spectrom 2013. (*corresponding author)

 

  • Krishna S, Nair A, Cheedipudi S, Poduval D, Dhawan J, Palakodeti D*, Ghanekar Y*. Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata. Nucleic Acids Res. 2013 Jan 7;41(1):599-616. *Co-Corresponding authors

 

  • Resch AM*, Palakodeti D*, Lu YC, Horowitz M, Graveley BR. Transcriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea. PLoS One. 2012;7(4):e34447. *Cofirst author

 

  • Resch A and Palakodeti D*. Small RNAs in planarian Schmidtea mediterranea. Intl Journal Dev Biol. 2012, 67-74. Invited review. * Corresponding author

 

  • Hollenbach JP, Resch AM, Palakodeti D, Graveley BR, Heinen CD. Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells. PLoS One. 2011;6(7):e21808.

 

  • Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR. microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. RNA. 2011 Aug;17(8):1529-43.

 

  • Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR. Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. RNA. 2009 Aug;15(8):1483-91. 

 

  • Palakodeti D, Smielewska M, Lu YC, Yeo GW, Graveley BR. The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians. RNA. 2008 Jun;14(6):1174-86.

 

  • Palakodeti D, Smielewska M, Graveley BR. MicroRNAs from the Planarian Schmidtea mediterranea: a model system for stem cell biology. RNA. 2006 Sep;12(9):1640-9.

Faculty