Laboratory Publications

Marcel N, Perumalsamy L, Shukla S and Sarin A
The lysine deacetylase Sirtuin 1 modulates the localization and function of the Notch1 receptor in regulatory T cells.
Science signaling 2017, 10 (473) eaah4679.
http://stke.sciencemag.org/cgi/content/summary/sigtrans;10/473/eaah4679?ijkey=sT6JpkeQsfoFg&keytype=ref&siteid=sigtrans

Marcel N and Sarin A
Notch1 regulated autophagy controls survival and suppressor activity of activated T-regulatory cells.
eLife 2016;5:e14023

Sarin A and Marcel N
The NOTCH1-Autophagy Interaction:Regulating self-eating for survival.
Invited article commentary in “Autophagic Puncta” for Autophagy, 2016, Issue 2 (p446-447) doi: 10.1080/15548627.2016.1268303

Garg M, Ramdas N, Vijayalakshmi M, Shivashankar GV, Sarin A
The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion
Cell Death Disease 2014, 13;5:e1058. doi: 10/1038/cddis

Garg M, Perumalsamy LR, Shivashankar GV, Sarin A
The linker histone H1.2 is an intermediate in the apoptotic response to cytokine deprivation in T-effectors.
Int. J. Cell Biol. 2014, 2014:674753. doi: 10.1155/2014/674753.

Purushothaman D*, Marcel N*, Garg M*, Venkataraman R, Sarin A
Apoptotic programs are determined during lineage commitment of CD4+ T-effectors: Selective regulation of T-effector-memory apoptosis by iNOS.
J. Immunol. 2013, 190 (1): 97-105. *equal contribution

Perumalsamy LR, Marcel N, Kulkarni K, Radtke F, Sarin A
Distinct spatial and molecular features of Notch pathway assembly in Regulatory T-cells
Science Signaling 2012, 5 (234): ra53

Gupta S*, Marcel N*, Sarin A, Shivashankar GV
Role of actin dependent nuclear deformation in regulating early gene expression
PLOS One, 2012, 7(12):e53031, *equal contribution

Gupta S*, Marcel N*, Talwar S*, Garg M, Indulaxmi R, Perumalsamy L, Sarin A, Shivashankar GV
Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration
PLOS One, 2012 10.1371/journal.pone.0043718 *equal contribution.

Perumalsamy LR, Nagala, M, Sarin A
A Notch activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival
Proc. Natl Acad Sci USA. 2010, 107:6882-6887. [Epub 2010 Mar 25]

Purushothanam D, Sarin A
Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis
J. Exp. Med. 2009, 206:1515-23

Perumalsamy LR, Nagala M, Bannerjee P, Sarin A
A hierarchical cascade activated by non-canonical Notch signaling and the mTOR - Rictor complex regulates neglect-induced death in mammalian cells
Cell Death & Differentiation 2009, 16:879-889 [doi: 10.1038/cdd.2009.20]

Srivastava S, Banerjee H, Chaudhry A, Khare A, Sarin A, George A, Bal V, Durdik JM, Rath S.
Apoptosis-inducing factor (Aif) regulates death in peripheral T cells
J. Immunol. 2007, 179: 797-803.

Rao J, Bhattacharya D, Banerjee B, Sarin A, Shivashankar GV.
Trichostatin-A induces differential changes in histone dynamics and expression in HeLa cells
BBRC, 2007, 363:263-8.

Parikh N, Koshy C, Dhayabharan V, Perumalsamy LR, Sowdhamini R, Sarin A.
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL
BMC Cell Biology. 2007 8:16.

Goyal G, Fell B, Sarin A, Youle RJ, Sriram V.
Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster Dev. Cell 2007, 12(5):807-16.

Geetha B*, Divya P*, Sade H, Gunasekharan V, Rangarajan A, Sarin A.
Evidence for a role for Notch signaling in the cytokine-dependent survival of activated T-cells
J. Immunol. 177: 2007, 5041-5050. *equal contribution

Parikh N, Sade H, Kurian L, Sarin A.
The Bax amino-terminus is required for negative regulation by the MEK and Akt signaling pathways in T cells
J. Immunol. 2004, 173:6220-6227.

Vig M, Srivastava S, Kandpal U, Sade H, Lewis V, Sarin A, George A, Bal V, Durdik JM, Rath S. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory
J. Clin. Invest. 2004, 113:1734-42.

Sade H, Sarin A.
Reactive oxygen species regulate quiescent T cell apoptosis via the BH3-only pro-apoptotic protein BIM
Cell Death and Differentiation 2004, 11: 416-423.

Sade H, Khandre NS, Mathew MK, Sarin A.
The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of ANT-independent and ANT-dependent events
Eur. J. Immunol. 2004, 34:119-125.

Sen A, Kuruvilla D, Pinto L, Sarin, Rodrigues V.
Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system
Mechanisms of Development 2004, 121: 65-78.

Sade H, Krishna S, Sarin A.
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signalling in T cells.
J. Biol. Chem. 2004, 279(4): 2937-2944.

Godbole A, Varghese J, Sarin A, Mathew MK
VDAC is a conserved element of death pathways in plant and animal systems
BBA. 2004, 1642:87-96.

Varghese J*, Khandre N*, Sarin A.
Caspase-3 activation is an early event and initiates apoptotic damage in a human leukemia cell line
Apoptosis 2003, 8:363-370. *equal contribution

Sade H, Sarin, A.
Interleukin-7 blocks caspase-independent apoptosis in mature T cells via phosphatidylinositol-3 kinase (PI-3K)-mediated survival signalling
Eur. J. Immunol. 2003, 33: 913-919.

Varghese J, Sade H, Vandenabeele P, Sarin A.
Head involution defective (Hid) triggered apoptosis requires caspase-8 but not FADD (Fas associated death domain) and is regulated by the extracellular signal-related kianse-I/2 (Erk) in mammalian cells
J. Biol. Chem. 2002, 277(38): 35097-104.

Varghese J, Radhika G, Sarin A
The role of calpain in caspase activation during etoposide induced apoptosis in T cells
Eur. J. Immunol. 2001, 31: 2035-2041.

Varghese J, Chattopadhyay S, Sarin A.
Inhibition of p38 kinase reveals a Tumour Necrosis Factor alpha (TNF) - mediated, caspase-dependent, apoptotic death pathway in a human myelomonocyte cell line
J. Immunol. 2001 166:6570-6577