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Indo-US Lab on Cardiovascular Medicine

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For a list of all publications Click here.
  • i-DHANS: Indian database of healthy aging nucleotide sequences

    Manuscript under preparation

    Indian database of healthy aging nucleotide sequences (i-DHANS) is the first Indian exome database for healthy aging individuals. It provides comprehensive information of different types of genetic variation on the Indian aging alleles that help to distinguish disease associated mutations. A total of 1500 control participants were analyzed and 94 healthy aging individuals were selected with the...

  • Myocardin ablation in a cardiac-renal rat model

    Sci Rep. 2019; 10;9(1):5872.

    Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased in DCM porcine and patient cardiac tissues and plays a crucial role in the pathophysiology of DCM. Inhibiting the increased MYOCD has shown to be partially rescuing the DCM phenotype in porcine model. However, expression levels of MYOCD in...

  • Database for Cardiomyopathy: CardioDatabase

    CardioDatabase is a comprehensive integrated platform for cardiomyopathy disease, which links dynamic information such as molecular pathogenesis, genetic variants and frequencies, modulation of important pathways, available therapies and therapeutic targets and basic information of disease associated genes. The information was collected in cohesive manner from different databases along with in-house curation. The...

  • Mir-19b-3p Regulates Autophagy by Targeting Raf-1 During Hypertrophic Cardiomyopathy

    Circulation Research. 2018;121:A484

    Hypertrophic cardiomyopathy (HCM) is a heterogenous disease predominantly caused by sarcomeric genes. However, 40-50% cases etiology are not known. RAF1 mutations cause syndromic and isolated childhood cardiomyopathies. Functional mutations in untranslated regions (UTRs) of RAF-1 gene are rare, and their role in cardiomyopathy is unexplored. UTRs are important sites for interaction of epigenetic regulators...

  • Raf1, a nexus for cardiac hypertrophic signaling in human disease

    In the current issue of the Journal of Molecular and Cellular Cardiology (July 2011), Dhandapany et al. further explore the ability of Raf1 to regulate hypertrophy of cardiomyocytes. The authors employ three common Raf1 mutations observed in Noonan/LEOPARD syndromes to dissect downstream signaling pathways ultimately impacting myocyte growth control.

    For more information

  • Children heart disease causing gene identified

    We discovered the variants in RAF1 (a RAS-MAPK member) as a primary cause of childhood-onset DCM (~10%). This is the first gene causing isolated DCM to be strongly associated with pediatric-onset disease and the first report of DCM principally attributable to altered RAS-MAPK signaling. Implications of these study on public health include various companies across the world use these variants as diagnostic
    markers to identify the risk associated with cardiomyopathies.

    ...

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVD through a multi-level approach.

  • Dr. Dhandapany Perundurai

    Principal Investigator

  • Dr. Anupam Mittal

    Post Doctoral Fellow

  • Dr. Ankit Sharma

    Post Doctoral Fellow

  • ,
    ,
    ,

    Dr. Kashyap Narayan

    Post Doctoral Fellow

  • Karthikeyan Sundaram

    Graduate Student

  • Prasanth Chimata

    Graduate Student

  • Deepak Kashyap

    Graduate Student

  • ,

    Dr. Aditi Jain

    Post Doctoral Fellow

  • Himani S

    Trainee @ OHSU

  • ,

    Dr. Karthikeyan Bose

    Post Doctoral Fellow @ OHSU

  • Pratul Jain

    Graduate Student

  • ,
    ,

    Sneha Khedkar

    Graduate Student

  • ,
    ,

    Arka Provo

    Junior Research Fellow

  • ,

    Paulami Dey

    Junior Research Fellow

 

Cardiovascular diseases (CVDs) are the leading cause of mortality globally. They are caused by various disorders of the heart and blood vessels. We are interested in understanding three major forms of CVDs including, cardiomyopathies, congenital heart disease and coronary heart disease (heart attacks).

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVDs through a multi-level approach.

The long-term goals of my group are to explore new genes, mechanisms and relevant drugs that have significant clinical and curative impact on CVDs.

WHAT WE DO?

 

Genetic Team

Identifying genes for CVDs

Ankit Sharma
Chiranjeevi M
Deepak Kashyap
Arka Provo
Karthik M
Aparna Mohan
 

 

 

 

Mechanistic Team

Signaling mechanism of CVDs

Anupam Mittal
Arka Provo 
Pratul Jain 
Karthik Bose 
Karthik M
Prasanth Chimata
Vigneshwar S
Kashyap Krishnasamy

 

Therapeutic Team

Targets for therapies and drug analysis

Karthik Bose
Sneha Khedkar
Anupam Mittal
Dennis Shi
Himani S
Kashyap Krishnasamy

Combatting cardiovascular disease by integrating genetics, basic science and clinical medicine.

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Currently, we are collaborating with various institutes, universities, medical colleges and hospitals as shown below for the patient samples and other reagents. We are also actively looking for new collaborations

If you are interested, please contact us at dhan@instem.res.in or perundur@ohsu.edu

  • National Center for Biological Sciences, Bangalore, Karnataka, India
  • Rajaji Medical College and Hospital, Madurai, Tamilnadu, India
  • Sri Jayadeva Institute of Cardiovascular Science and Research, Bangalore, Karnataka, India
  • Center for Human Genetics, Bangalore, Karnataka, India
  • Narayana Hrudayalaya, Bangalore, Karnataka, India
  • Calicut Medical College, Kozhikode, Kerala, India
  • Amrita Institute of Medical Sciences, Cochin, Kerala, India 
  • Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
  • Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India
  • Oregon Health and Science University, Portland, USA
  • Harvard Medical School, Boston, Massachusetts, USA
  • Icahn School of Medicine at Mount Sinai, New York, USA
  • Broad Institute, Cambridge, Massachusetts, USA
  • Stanford University, Stanford, California, USA
  • University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
  • University of California, San Francisco, California, USA
  • University of Oxford, Oxford, UK

 

 

 

Dr. Dhandapany Perundurai

 

 

Institute for Stem Cell Science and Regenerative Medicine (InStem),
National Centre for Biological Sciences (NCBS),
GKVK - Post, Bellary Road, Bangalore 560065, India.
Email: dhan@instem.res.in

 

Department of Molecular and Medical Genetics
Knight Cardiovascular Institute (KCVI), Oregon Health & Sciences University
3181 SW Sam Jackson Park Road L103, Portland, Oregon, U.S.A. 97239-3098
Email: perundur@ohsu.edu