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CardioGenomics,Stem Cells and Precision Medicine Lab

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CardioGenomics,Stem Cells and Precision Medicine Lab

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A recent study from our lab showed that sleep fragmentation in patients with hypertrophic cardiomyopathy increases their risk for heart failure.

Deccan Herald; read the news article here

Times Of India; read the news article here

Deccan Herald; read the news article here
 

In a collaborative effort with researchers from our lab at inStem and NCBS, a study published in PNAS showed that air pollutants cause irregular heartbeats in bees and mis-expression of cardiac ion channel genes. This is alarming as such an effect might have huge implications on human heart health also.

Times Of India; read the news article here

Our work on the molecular genetics of cardiomyopathies led to a major discovery as we unraveled an ancient Myosin Binding Protein c3 (MYBPC3) gene deletion as a major risk factor for South Asians. To date, approximately 60 million people carry the heterozygous deletion. This variant, in its homozygous nature, causes severe childhood cardiomyopathies. Of note, this discovery was the subject of a documentary by Dr. Sanjay Gupta of CNN.

Please click the youtube video shown below for more details.

We discovered the variants in RAF1 (a RAS-MAPK member) as a primary cause of childhood-onset DCM (~10%). This is the first gene causing isolated DCM to be strongly associated with pediatric-onset disease and the first report of DCM principally attributable to altered RAS-MAPK signaling. Implications of these study on public health include various companies across the world use these variants as diagnostic
markers to identify the risk associated with cardiomyopathies.

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVD through a multi-level approach.

  • Prof. Dhandapany Perundurai

    Associate Professor and Scientist F

  • Prasanth Chimata

    Graduate Student

  • Pratul Jain

    Graduate Student

  • Harshil Chittora

    Graduate Student

  • Vinay J Rao

    Graduate Student

  • Dr. Thiagarajan Sairam

    Post Doctoral Fellow

  • Radhika Agrawal

    Graduate Student

  • Saswata Bhattacharyya

    Graduate Student

  • Saptashwa Chakrabarti

    Graduate Student

  • Dr. Kavitha Govarthanan

    Post Doctoral Fellow

  • Vismaya Vimbi

    Graduate Student

  • Steffi Christiane

    Post Doctoral Fellow

  • Guna K

    Graduate Student

  • Mr. Pratul Kumar Jain of Perundurai lab at inStem has won the first prize in an oral presentation with a cash prize of ₹ 10000 at The Heart Failure Conflux 2023 held on 4th and 5th of February 2023, organized by Heart Failure Association of India (HFAI) and Indian Council of Medical Research – Centre for Advanced Research (ICMR-CARE).

  • Mrs. Kavitha Govarthanan of Perundurai lab at Cardiovascular development and disease mechanisms has received the Madhu Khullar “Women Scientist Early Career Award” with a cash prize of ₹ 10000 at the Advances in Cardiovascular Medicine and Research (ACMR) 2023 held on 16th to 18th February 2023, organized by International Society for Heart Research (ISHR) and International Academy of Cardiovascular Sciences (IACS).

  • Mr. Prasanth Chimata of Perundurai lab at Cardiovascular development and disease mechanisms has won the second prize in the N K Ganguly oral presentation award with a cash prize of ₹ 3000 category at the Advances in Cardiovascular Medicine and Research (ACMR) 2023 held on 16th to 18th February 2023, organized by International Society for Heart Research (ISHR) and International Academy of Cardiovascular Sciences (IACS).

  • Mr. Vinay J Rao of Perundurai lab at Cardiovascular development and disease mechanisms has won the first prize in poster presentation with a cash prize of ₹ 3000 at the Advances in Cardiovascular Medicine and Research (ACMR) 2023 held on 16th to 18th February 2023, organized by International Society for Heart Research (ISHR) and International Academy of Cardiovascular Sciences (IACS).

  • Mr. Pratul Kumar Jain of Perundurai lab at inStem has received the Prof C C Kartha travel award with a cash prize of ₹ 3000 at the Advances in Cardiovascular Medicine and Research (ACMR) 2023 held on 16th to 18th February 2023, organized by International Society for Heart Research (ISHR) and International Academy of Cardiovascular Sciences (IACS).

  • Mr. Saswata Bhattacharyya of Perundurai lab at inStem has received the Prof C C Kartha travel award with a cash prize of ₹ 3000 at the Advances in Cardiovascular Medicine and Research (ACMR) 2023 held on 16th to 18th February 2023, organized by International Society for Heart Research (ISHR) and International Academy of Cardiovascular Sciences (IACS).

  • We are organizing the International Cardiovascular Medicine Summit on the 4th and 5th of March 2024 at inStem

  • The schedule for the International Cardiovascular Medicine Summit, 2024 happening on the 4th and 5th of March, 2024

  • Perundurai lab on Christmas Eve, 2022

  • Celebration of Prof. Perundurai's tenure, Feb 2023

  • Perundurai lab meeting its alumnus, Dr. Anupam Mittal before ACMR 2023 at Chandigarh, Feb 2022

  • Perundurai lab celebrating poster awards, April 2023

 

Cardiovascular diseases (CVDs) are the leading cause of mortality globally. They are caused by various disorders of the heart and blood vessels. We are interested in understanding three major forms of CVDs including, cardiomyopathies, congenital heart disease and coronary heart disease (heart attacks).

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVDs through a multi-level approach.

The long-term goals of my group are to explore new genes, mechanisms and relevant drugs that have significant clinical and curative impact on CVDs.

WHAT WE DO?

 

Genetic Team

Identifying genes for CVDs

Vinay J Rao
Shashank J 
Thiagarajan S

 

 

 

 

 

 

Mechanistic Team

Signaling mechanism of CVDs

Pratul K Jain
Prasanth Chimata 
Harshil Chittora
Vinay J Rao
Radhika Agrawal
Shashank J
Saptashwa Chakrabarti
Saswata Bhattacharyya
 

 

Therapeutic Team

Targets for therapies and drug analysis

Pratul K Jain
Prasanth Chimata
Radhika Agrawal
Saptashwa Chakrabarti

Combatting cardiovascular disease by integrating genetics, basic science and clinical medicine.

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Currently, we are collaborating with various institutes, universities, medical colleges and hospitals as shown below for the patient samples and other reagents. We are also actively looking for new collaborations

If you are interested, please contact us at dhan@instem.res.in or perundur@ohsu.edu

  • National Center for Biological Sciences, Bangalore, Karnataka, India
  • Rajaji Medical College and Hospital, Madurai, Tamilnadu, India
  • Sri Jayadeva Institute of Cardiovascular Science and Research, Bangalore, Karnataka, India
  • Center for Human Genetics, Bangalore, Karnataka, India
  • Narayana Hrudayalaya, Bangalore, Karnataka, India
  • Calicut Medical College, Kozhikode, Kerala, India
  • Amrita Institute of Medical Sciences, Cochin, Kerala, India 
  • Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
  • Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India
  • Oregon Health and Science University, Portland, USA
  • Harvard Medical School, Boston, Massachusetts, USA
  • Icahn School of Medicine at Mount Sinai, New York, USA
  • Broad Institute, Cambridge, Massachusetts, USA
  • Stanford University, Stanford, California, USA
  • University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
  • University of California, San Francisco, California, USA
  • University of Oxford, Oxford, UK

 

 

 

Dr. Dhandapany Perundurai

 

 

Institute for Stem Cell Science and Regenerative Medicine (InStem),
National Centre for Biological Sciences (NCBS),
GKVK - Post, Bellary Road, Bangalore 560065, India.
Email: dhan@instem.res.in

 

Department of Molecular and Medical Genetics
Knight Cardiovascular Institute (KCVI), Oregon Health & Sciences University
3181 SW Sam Jackson Park Road L103, Portland, Oregon, U.S.A. 97239-3098
Email: perundur@ohsu.edu

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WHAT WE DO?

Web Design

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Web developement

Cras metus sem, mattis et volutpat ac, dignissim quis arcu. Fusce pretium suscipit mauris, in rhoncus arcu. Pellentesque malesuada dolor a lorem ultrices dapibus vel eget neque.

Marketing

Cras metus sem, mattis et volutpat ac, dignissim quis arcu. Fusce pretium suscipit mauris, in rhoncus arcu. Pellentesque malesuada dolor a lorem ultrices dapibus vel eget neque.

Donec id augue lectus. Integer laoreet urna tincidunt sem suscipit, pretium congue nunc dapibus. Proin ac pretium quam. Sed in metus quis elit elementum vestibulum. Quisque tincidunt, ante a egestas venenatis, est neque mattis nisl, ut volutpat turpis erat ac neque.

In hac habitasse platea dictumst. Pellentesque in aliquet risus. In at consequat ipsum. Aenean leo elit, imperdiet ac volutpat ornare, mattis vel est. Aliquam rhoncus mi non tortor sodales placerat vel in dolor. Praesent lorem tellus, porta vitae enim sit amet, interdum imperdiet.

Table Header Table Header Table Header Table Header
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Content Goes Here This is longer Content Goes Here Donec id elit non mi porta gravida at eget metus. Content Goes Here Content Goes Here

WHAT WE DO?

Web Design

Cras metus sem, mattis et volutpat ac, dignissim quis arcu. Fusce pretium suscipit mauris, in rhoncus arcu. Pellentesque malesuada dolor a lorem ultrices dapibus vel eget neque.

Web developement

Cras metus sem, mattis et volutpat ac, dignissim quis arcu. Fusce pretium suscipit mauris, in rhoncus arcu. Pellentesque malesuada dolor a lorem ultrices dapibus vel eget neque.

Marketing

Cras metus sem, mattis et volutpat ac, dignissim quis arcu. Fusce pretium suscipit mauris, in rhoncus arcu. Pellentesque malesuada dolor a lorem ultrices dapibus vel eget neque.

Donec id augue lectus. Integer laoreet urna tincidunt sem suscipit, pretium congue nunc dapibus. Proin ac pretium quam. Sed in metus quis elit elementum vestibulum. Quisque tincidunt, ante a egestas venenatis, est neque mattis nisl, ut volutpat turpis erat ac neque.