Next generation sequencing reveals NRAP as a candidate gene for hypertrophic cardiomyopathy in elderly patients
Hypertrophic cardiomyopathy (HCM) is a heterogenous heart muscle disease predominantly caused by sarcomeric protein encoding genes. However, the cause for a significant number of elderly patients remains unclear. Here, we performed whole-exome sequencing in a South Indian family with an elderly HCM proband. We identified a heterozygous...
Manuscript under preparation
Indian database of healthy aging nucleotide sequences (i-DHANS) is the first Indian exome database for healthy aging individuals. It provides comprehensive information of different types of genetic variation on the Indian aging alleles that help to distinguish disease associated mutations. A total of 1500 control participants were analyzed and 94 healthy aging individuals were selected with the...
Sci Rep. 2019; 10;9(1):5872.
Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased in DCM porcine and patient cardiac tissues and plays a crucial role in the pathophysiology of DCM. Inhibiting the increased MYOCD has shown to be partially rescuing the DCM phenotype in porcine model. However, expression levels of MYOCD in...
CardioDatabase is a comprehensive integrated platform for cardiomyopathy disease, which links dynamic information such as molecular pathogenesis, genetic variants and frequencies, modulation of important pathways, available therapies and therapeutic targets and basic information of disease associated genes. The information was collected in cohesive manner from different databases along with in-house curation. The...
Circulation Research. 2018;121:A484
Hypertrophic cardiomyopathy (HCM) is a heterogenous disease predominantly caused by sarcomeric genes. However, 40-50% cases etiology are not known. RAF1 mutations cause syndromic and isolated childhood cardiomyopathies. Functional mutations in untranslated regions (UTRs) of RAF-1 gene are rare, and their role in cardiomyopathy is unexplored. UTRs are important sites for interaction of epigenetic regulators...
In the current issue of the Journal of Molecular and Cellular Cardiology (July 2011), Dhandapany et al. further explore the ability of Raf1 to regulate hypertrophy of cardiomyocytes. The authors employ three common Raf1 mutations observed in Noonan/LEOPARD syndromes to dissect downstream signaling pathways ultimately impacting myocyte growth control.
We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVD through a multi-level approach.
Dr. Dhandapany Perundurai
Dr. Ankit Sharma
Post Doctoral Fellow
Dr. Aditi Jain
Post Doctoral Fellow
Trainee @ OHSU
Dr. Karthikeyan Bose
Post Doctoral Fellow @ OHSU
Cardiovascular diseases (CVDs) are the leading cause of mortality globally. They are caused by various disorders of the heart and blood vessels. We are interested in understanding three major forms of CVDs including, cardiomyopathies, congenital heart disease and coronary heart disease (heart attacks).
We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVDs through a multi-level approach.
The long-term goals of my group are to explore new genes, mechanisms and relevant drugs that have significant clinical and curative impact on CVDs.
WHAT WE DO?
Identifying genes for CVDs
Signaling mechanism of CVDs
Targets for therapies and drug analysis
Combatting cardiovascular disease by integrating genetics, basic science and clinical medicine.
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Currently, we are collaborating with various institutes, universities, medical colleges and hospitals as shown below for the patient samples and other reagents. We are also actively looking for new collaborations
- National Center for Biological Sciences, Bangalore, Karnataka, India
- Rajaji Medical College and Hospital, Madurai, Tamilnadu, India
- Sri Jayadeva Institute of Cardiovascular Science and Research, Bangalore, Karnataka, India
- Center for Human Genetics, Bangalore, Karnataka, India
- Narayana Hrudayalaya, Bangalore, Karnataka, India
- Calicut Medical College, Kozhikode, Kerala, India
- Amrita Institute of Medical Sciences, Cochin, Kerala, India
- Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
- Postgraduate Institute of Medical Education and Research, Chandigarh, India
- Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India
- Oregon Health and Science University, Portland, USA
- Harvard Medical School, Boston, Massachusetts, USA
- Icahn School of Medicine at Mount Sinai, New York, USA
- Broad Institute, Cambridge, Massachusetts, USA
- Stanford University, Stanford, California, USA
- University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
- University of California, San Francisco, California, USA
- University of Oxford, Oxford, UK
Dr. Dhandapany Perundurai
Institute for Stem Cell Science and Regenerative Medicine (InStem),
National Centre for Biological Sciences (NCBS),
GKVK - Post, Bellary Road, Bangalore 560065, India.
Department of Molecular and Medical Genetics
Knight Cardiovascular Institute (KCVI), Oregon Health & Sciences University
3181 SW Sam Jackson Park Road L103, Portland, Oregon, U.S.A. 97239-3098