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CardioGenomics,Stem Cells and Precision Medicine Lab

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CardioGenomics,Stem Cells and Precision Medicine Lab

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Times Of India; read the news article here

Deccan Herald; read the news article here
 

In a collaborative effort with researchers from our lab at inStem and NCBS, a study published in PNAS showed that air pollutants cause irregular heartbeats in bees and mis-expression of cardiac ion channel genes. This is alarming as such an effect might have huge implications on human heart health also.

Times Of India; read the news article here

Our work on the molecular genetics of cardiomyopathies led to a major discovery as we unraveled an ancient Myosin Binding Protein c3 (MYBPC3) gene deletion as a major risk factor for South Asians. To date, approximately 60 million people carry the heterozygous deletion. This variant, in its homozygous nature, causes severe childhood cardiomyopathies. Of note, this discovery was the subject of a documentary by Dr. Sanjay Gupta of CNN.

Please click the youtube video shown below for more details.

We discovered the variants in RAF1 (a RAS-MAPK member) as a primary cause of childhood-onset DCM (~10%). This is the first gene causing isolated DCM to be strongly associated with pediatric-onset disease and the first report of DCM principally attributable to altered RAS-MAPK signaling. Implications of these study on public health include various companies across the world use these variants as diagnostic
markers to identify the risk associated with cardiomyopathies.

In the current issue of the Journal of Molecular and Cellular Cardiology (July 2011), Dhandapany et al. further explore the ability of Raf1 to regulate hypertrophy of cardiomyocytes. The authors employ three common Raf1 mutations observed in Noonan/LEOPARD syndromes to dissect downstream signaling pathways ultimately impacting myocyte growth control.

For more information

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVD through a multi-level approach.

  • Prof. Dhandapany Perundurai

    Associate Professor and Scientist F

  • Prasanth Chimata

    Graduate Student

  • Pratul Jain

    Graduate Student

  • Harshil Chittora

    Graduate Student

  • Vinay J Rao

    Graduate Student

  • Dr. Thiagarajan Sairam

    Post Doctoral Fellow

  • Radhika Agrawal

    Junior Research Fellow

  • Saswata Bhattacharyya

    Graduate Student

  • Saptashwa Chakrabarti

    Graduate Student

  • Dr. Kavitha Govarthanan

    Post Doctoral Fellow

  • Lekha Kandasami

    Project Associate

 

Cardiovascular diseases (CVDs) are the leading cause of mortality globally. They are caused by various disorders of the heart and blood vessels. We are interested in understanding three major forms of CVDs including, cardiomyopathies, congenital heart disease and coronary heart disease (heart attacks).

We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVDs through a multi-level approach.

The long-term goals of my group are to explore new genes, mechanisms and relevant drugs that have significant clinical and curative impact on CVDs.

WHAT WE DO?

 

Genetic Team

Identifying genes for CVDs

Vinay J Rao
Shashank J 
Thiagarajan S

 

 

 

 

 

 

Mechanistic Team

Signaling mechanism of CVDs

Pratul K Jain
Prasanth Chimata 
Harshil Chittora
Vinay J Rao
Radhika Agrawal
Shashank J
Lekha Kandasami
Saptashwa Chakrabarti
Saswata Bhattacharyya
 

 

Therapeutic Team

Targets for therapies and drug analysis

Pratul K Jain
Prasanth Chimata
Radhika Agrawal
Lekha Kandasami
Saptashwa Chakrabarti

Combatting cardiovascular disease by integrating genetics, basic science and clinical medicine.

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Currently, we are collaborating with various institutes, universities, medical colleges and hospitals as shown below for the patient samples and other reagents. We are also actively looking for new collaborations

If you are interested, please contact us at dhan@instem.res.in or perundur@ohsu.edu

  • National Center for Biological Sciences, Bangalore, Karnataka, India
  • Rajaji Medical College and Hospital, Madurai, Tamilnadu, India
  • Sri Jayadeva Institute of Cardiovascular Science and Research, Bangalore, Karnataka, India
  • Center for Human Genetics, Bangalore, Karnataka, India
  • Narayana Hrudayalaya, Bangalore, Karnataka, India
  • Calicut Medical College, Kozhikode, Kerala, India
  • Amrita Institute of Medical Sciences, Cochin, Kerala, India 
  • Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
  • Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India
  • Oregon Health and Science University, Portland, USA
  • Harvard Medical School, Boston, Massachusetts, USA
  • Icahn School of Medicine at Mount Sinai, New York, USA
  • Broad Institute, Cambridge, Massachusetts, USA
  • Stanford University, Stanford, California, USA
  • University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
  • University of California, San Francisco, California, USA
  • University of Oxford, Oxford, UK

 

 

 

Dr. Dhandapany Perundurai

 

 

Institute for Stem Cell Science and Regenerative Medicine (InStem),
National Centre for Biological Sciences (NCBS),
GKVK - Post, Bellary Road, Bangalore 560065, India.
Email: dhan@instem.res.in

 

Department of Molecular and Medical Genetics
Knight Cardiovascular Institute (KCVI), Oregon Health & Sciences University
3181 SW Sam Jackson Park Road L103, Portland, Oregon, U.S.A. 97239-3098
Email: perundur@ohsu.edu