Next generation sequencing reveals NRAP as a candidate gene for hypertrophic cardiomyopathy in elderly patients
https://doi.org/10.1101/789065
Hypertrophic cardiomyopathy (HCM) is a heterogenous heart muscle disease predominantly caused by sarcomeric protein encoding genes. However, the cause for a significant number of elderly patients remains unclear. Here, we performed whole-exome sequencing in a South Indian family with an elderly HCM proband. We identified a heterozygous...
i-DHANS: Indian database of healthy aging nucleotide sequences
Manuscript under preparation
Indian database of healthy aging nucleotide sequences (i-DHANS) is the first Indian exome database for healthy aging individuals. It provides comprehensive information of different types of genetic variation on the Indian aging alleles that help to distinguish disease associated mutations. A total of 1500 control participants were analyzed and 94 healthy aging individuals were selected with the...
Myocardin ablation in a cardiac-renal rat model
Sci Rep. 2019; 10;9(1):5872.
Dilated cardiomyopathy (DCM) is a major co-existing form of heart failure (HF) with renal diseases. Myocardin (MYOCD), a cardiac-specific co-activator of serum response factor (SRF), is increased in DCM porcine and patient cardiac tissues and plays a crucial role in the pathophysiology of DCM. Inhibiting the increased MYOCD has shown to be partially rescuing the DCM phenotype in porcine model. However, expression levels of MYOCD in...
Database for Cardiomyopathy: CardioDatabase
CardioDatabase is a comprehensive integrated platform for cardiomyopathy disease, which links dynamic information such as molecular pathogenesis, genetic variants and frequencies, modulation of important pathways, available therapies and therapeutic targets and basic information of disease associated genes. The information was collected in cohesive manner from different databases along with in-house curation. The...
Mir-19b-3p Regulates Autophagy by Targeting Raf-1 During Hypertrophic Cardiomyopathy
Circulation Research. 2018;121:A484
Hypertrophic cardiomyopathy (HCM) is a heterogenous disease predominantly caused by sarcomeric genes. However, 40-50% cases etiology are not known. RAF1 mutations cause syndromic and isolated childhood cardiomyopathies. Functional mutations in untranslated regions (UTRs) of RAF-1 gene are rare, and their role in cardiomyopathy is unexplored. UTRs are important sites for interaction of epigenetic regulators...
Raf1, a nexus for cardiac hypertrophic signaling in human disease
In the current issue of the Journal of Molecular and Cellular Cardiology (July 2011), Dhandapany et al. further explore the ability of Raf1 to regulate hypertrophy of cardiomyocytes. The authors employ three common Raf1 mutations observed in Noonan/LEOPARD syndromes to dissect downstream signaling pathways ultimately impacting myocyte growth control.
-
Cardiovascular diseases
-
South Asian Cardiovascular Genetic Consortium
-
Bioinformatics tools to identify disease genes
-
Genome editing of novel variants associated with cardiomyopathy using CRISPR-CAS9 system
-
Functional characterization of cardiomyopathies using patient specific induced pluripotent stem cells (hiPSCs)
-
Role of RAF1/SHOC2 in cardiomyopathy
-
An in vivo large- scale small molecules screening using Drosophila model
-
Humanized transgenic mice models of cardiomyopathy
We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVD through a multi-level approach.
Dr. Dhandapany Perundurai
Principal Investigator
Dr. Ankit Sharma
Post Doctoral Fellow
Karthikeyan Sundaram
Graduate Student
Prasanth Chimata
Graduate Student
Deepak Kashyap
Graduate Student
, 
Dr. Aditi Jain
Post Doctoral Fellow
Himani S
Trainee @ OHSU
, 
Dr. Karthikeyan Bose
Post Doctoral Fellow @ OHSU
Pratul Jain
Graduate Student
, 
, 
Sneha Khedkar
Graduate Student
Cardiovascular diseases (CVDs) are the leading cause of mortality globally. They are caused by various disorders of the heart and blood vessels. We are interested in understanding three major forms of CVDs including, cardiomyopathies, congenital heart disease and coronary heart disease (heart attacks).
We are a multi-disciplinary team including Geneticists, Clinicians, Bioinformaticians, Engineers, Biochemists, Biophysicists, and Molecular Biologists addressing CVDs through a multi-level approach.
The long-term goals of my group are to explore new genes, mechanisms and relevant drugs that have significant clinical and curative impact on CVDs.
WHAT WE DO?
Genetic Team
Identifying genes for CVDs
Ankit Sharma
Chiranjeevi M
Deepak Kashyap
Arka Provo
Karthik M
Aparna Mohan
Mechanistic Team
Signaling mechanism of CVDs
Anupam Mittal
Arka Provo
Pratul Jain
Karthik Bose
Karthik M
Prasanth Chimata
Vigneshwar S
Kashyap Krishnasamy
Therapeutic Team
Targets for therapies and drug analysis
Karthik Bose
Sneha Khedkar
Anupam Mittal
Dennis Shi
Himani S
Kashyap Krishnasamy
Combatting cardiovascular disease by integrating genetics, basic science and clinical medicine.
Donec id augue lectus. Integer laoreet urna tincidunt sem suscipit, pretium congue nunc dapibus. Proin ac pretium quam. Sed in metus quis elit elementum vestibulum. Quisque tincidunt, ante a egestas venenatis, est neque mattis nisl, ut volutpat turpis erat ac neque.
Currently, we are collaborating with various institutes, universities, medical colleges and hospitals as shown below for the patient samples and other reagents. We are also actively looking for new collaborations
If you are interested, please contact us at dhan@instem.res.in or perundur@ohsu.edu
- National Center for Biological Sciences, Bangalore, Karnataka, India
- Rajaji Medical College and Hospital, Madurai, Tamilnadu, India
- Sri Jayadeva Institute of Cardiovascular Science and Research, Bangalore, Karnataka, India
- Center for Human Genetics, Bangalore, Karnataka, India
- Narayana Hrudayalaya, Bangalore, Karnataka, India
- Calicut Medical College, Kozhikode, Kerala, India
- Amrita Institute of Medical Sciences, Cochin, Kerala, India
- Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
- Postgraduate Institute of Medical Education and Research, Chandigarh, India
- Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India
- Oregon Health and Science University, Portland, USA
- Harvard Medical School, Boston, Massachusetts, USA
- Icahn School of Medicine at Mount Sinai, New York, USA
- Broad Institute, Cambridge, Massachusetts, USA
- Stanford University, Stanford, California, USA
- University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
- University of California, San Francisco, California, USA
- University of Oxford, Oxford, UK
Dr. Dhandapany Perundurai
Institute for Stem Cell Science and Regenerative Medicine (InStem),
National Centre for Biological Sciences (NCBS),
GKVK - Post, Bellary Road, Bangalore 560065, India.
Email: dhan@instem.res.in
Department of Molecular and Medical Genetics
Knight Cardiovascular Institute (KCVI), Oregon Health & Sciences University
3181 SW Sam Jackson Park Road L103, Portland, Oregon, U.S.A. 97239-3098
Email: perundur@ohsu.edu