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Humanized transgenic mice models of cardiomyopathy
We have generated three humanized cardiac-specific transgenic mouse models of cardiomyopathy using standard Cre-loxP recombination methods. We are characterizing the physiological, functional and molecular aspects of these mice models specifically we are studying the following pathological hypertrophic parameters
- Enlargement of cardiomyocytes
- Reactivation of fetal genes
- Fibrosis of extracellular matrix
- Sarcomeric reorganization
- Activation of MAPkinase pathways
- Decreased cardiac function
We are also using these pre-clinical models for translational research.