A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.
Title | A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB |
Journal | Elife |
Volume | 9 |
Date Published | 2020 Jan 15 |
ISSN | 2050-084X |
Abstract | SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency. |
DOI | 10.7554/eLife.52656 |
Alternate Journal | Elife |
PubMed ID | 31939740 |
PubMed Central ID | PMC6994236 |
Grant List | MH15456 / MH / NIMH NIH HHS / United States Professorship / / Allen and Lenabelle Davis Foundation / Postdoctoral Fellowship / / National Science Foundation / Grant 529085 / / Simons Foundation / MR/P006213/1 / MRC_ / Medical Research Council / United Kingdom MH15456 / MH / NIMH NIH HHS / United States Patrick Wild Centre / / Patrick Wild Centre / |