TitleNMDA receptor function in inhibitory neurons.
Publication TypeJournal Article
Year of Publication2021
AuthorsBooker SA, Wyllie DJA
Date Published2021 Sep 15
KeywordsAnimals, Brain, Cerebral Cortex, GABAergic Neurons, Hippocampus, Humans, Interneurons, Neural Inhibition, Neural Pathways, Neurons, Receptors, N-Methyl-D-Aspartate

N-methyl-d-aspartate receptors (NMDARs) are present in the majority of brain circuits and play a key role in synaptic information transfer and synaptic plasticity. A key element of many brain circuits are inhibitory GABAergic interneurons that in themselves show diverse and cell-type-specific NMDAR expression and function. Indeed, NMDARs located on interneurons control cellular excitation in a synapse-type specific manner which leads to divergent dendritic integration properties amongst the plethora of interneuron subtypes known to exist. In this review, we explore the documented diversity of NMDAR subunit expression in identified subpopulations of interneurons and assess the NMDAR subtype-specific control of their function. We also highlight where knowledge still needs to be obtained, if a full appreciation is to be gained of roles played by NMDARs in controlling GABAergic modulation of synaptic and circuit function. This article is part of the 'Special Issue on Glutamate Receptors - NMDA receptors'.

Alternate JournalNeuropharmacology
PubMed ID34000273
Grant ListBB/N015878/10 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/P006213/1 / MRC_ / Medical Research Council / United Kingdom