Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival.
|Title||Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Saini N, Naaz A, Metur SPadma, Gahlot P, Walvekar A, Dutta A, Davathamizhan U, Sarin A, Laxman S|
|Journal||Life Sci Alliance|
|Date Published||2022 Sep 09|
|Keywords||Interleukin-2, Methionine, Racemethionine, Solute Carrier Proteins, T-Lymphocytes, Regulatory|
Cell death, survival, or growth decisions in T-cell subsets depend on interplay between cytokine-dependent and metabolic processes. The metabolic requirements of T-regulatory cells (Tregs) for their survival and how these are satisfied remain unclear. Herein, we identified a necessary requirement of methionine uptake and usage for Tregs survival upon IL-2 deprivation. Activated Tregs have high methionine uptake and usage to S-adenosyl methionine, and this uptake is essential for Tregs survival in conditions of IL-2 deprivation. We identify a solute carrier protein SLC43A2 transporter, regulated in a Notch1-dependent manner that is necessary for this methionine uptake and Tregs viability. Collectively, we uncover a specifically regulated mechanism of methionine import in Tregs that is required for cells to adapt to cytokine withdrawal. We highlight the need for methionine availability and metabolism in contextually regulating cell death in this immunosuppressive population of T cells.
|Alternate Journal||Life Sci Alliance|
|PubMed Central ID||PMC9463494|