TitleMetabolic control of cellular immune-competency by odors in .
Publication TypeJournal Article
Year of Publication2020
AuthorsMadhwal S, Shin M, Kapoor A, Goyal M, Joshi MK, Rehman PMujeeb Ur, Gor K, Shim J, Mukherjee T
JournalElife
Volume9
Date Published2020 12 29
ISSN2050-084X
Abstract

Studies in different animal model systems have revealed the impact of odors on immune cells; however, any understanding on why and how odors control cellular immunity remained unclear. We find that employ an olfactory-immune cross-talk to tune a specific cell type, the lamellocytes, from hematopoietic-progenitor cells. We show that neuronally released GABA derived upon olfactory stimulation is utilized by blood-progenitor cells as a metabolite and through its catabolism, these cells stabilize Sima/HIFα protein. Sima capacitates blood-progenitor cells with the ability to initiate lamellocyte differentiation. This systemic axis becomes relevant for larvae dwelling in wasp-infested environments where chances of infection are high. By co-opting the olfactory route, the preconditioned animals elevate their systemic GABA levels leading to the upregulation of blood-progenitor cell Sima expression. This elevates their immune-potential and primes them to respond rapidly when infected with parasitic wasps. The present work highlights the importance of the olfaction in immunity and shows how odor detection during animal development is utilized to establish a long-range axis in the control of blood-progenitor competency and immune-priming.

DOI10.7554/eLife.60376
Alternate JournalElife
PubMed ID33372660
PubMed Central IDPMC7808736
Grant ListDBT/PR13446/COE/34/30/2015 / / Department of Biotechnology, Ministry of Science and Technology, India / International
DST/ECR/2015/000390 / / Department of Science and Technology, Ministry of Science and Technology, India / International
Ramalingaswami Fellowship / / Department of Biotechnology, Ministry of Science and Technology, India / International
DBT/PR13446/COE/34/30/2015 / / Department of Biotechnology , Ministry of Science and Technology / International
DST/ECR/2015/000390 / / Department of Science and Technology, Ministry of Science and Technology / International
Ramalingaswami Fellowship / / Department of Biotechnology , Ministry of Science and Technology / International
000390DBT-IYBA 2017 / / DBT-The Innovative Young Biotechnologist Award (IYBA)2017 / International
CEFIPRA / / Centre Franco-Indien pour la Promotion de la Recherche Avancée / International
NRF2014S1A2A2028388 / / National Research Foundation / International
NRF-2017R1C1B2007343 / / National Research Foundation / International