TitleExosomes: mobile platforms for targeted and synergistic signaling across cell boundaries.
Publication TypeJournal Article
Year of Publication2017
AuthorsVyas N, Dhawan J
JournalCell Mol Life Sci
Date Published2017 05
KeywordsAnimals, Cell Communication, Cell Membrane, Exosomes, Humans, Models, Biological, RNA, Signal Transduction

Intercellular communications play a vital role during tissue patterning, tissue repair, and immune reactions, in homeostasis as well as in disease. Exosomes are cell-derived secreted vesicles, extensively studied for their role in intercellular communication. Exosomes have the intrinsic ability to package multiple classes of proteins and nucleic acids within their lumens and on their membranes. Here, we explore the hypothesis that exosomal targeting may represent a cellular strategy that has evolved to deliver specific combinations of signals to specific target cells and influence normal or pathological processes. This review aims to evaluate the available evidence for this hypothesis and to identify open questions whose answers will illuminate our understanding and applications of exosome biology.

Alternate JournalCell. Mol. Life Sci.
PubMed ID27826642
Grant List / / Wellcome Trust-DBT India Alliance / India