DDX24 is required for muscle fiber organization and the suppression of wound-induced Wnt activity necessary for pole re-establishment during planarian regeneration.
| Title | DDX24 is required for muscle fiber organization and the suppression of wound-induced Wnt activity necessary for pole re-establishment during planarian regeneration. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Sarkar SR, Dubey VKumar, Jahagirdar A, Lakshmanan V, Haroon MMohamed, Sowndarya S, Sowdhamini R, Palakodeti D |
| Journal | Dev Biol |
| Volume | 488 |
| Pagination | 11-29 |
| Date Published | 2022 May 04 |
| ISSN | 1095-564X |
| Abstract | Planarians have a remarkable ability to undergo whole-body regeneration. Successful regeneration outcome is determined by processes like polarity establishment at the wound site, which is followed by pole (organizer) specification. Interestingly, these determinants are almost exclusively expressed by muscles in these animals. However, the molecular toolkit that enables the functional versatility of planarian muscles remains poorly understood. Here we report that SMED_DDX24, a D-E-A-D Box RNA helicase, is necessary for planarian survival and regeneration. We found that DDX24 is enriched in muscles and its knockdown disrupts muscle fiber organization. This leads to defective pole specification, which in turn results in misregulation of many positional control genes specifically during regeneration. ddx24 RNAi also upregulates wound-induced Wnt signalling. Suppressing this ectopic Wnt activity rescues the knockdown phenotype by enabling better anterior pole regeneration. To summarize, our work highlights the role of an RNA helicase in muscle fiber organization, and modulating amputation-induced wnt levels, both of which seem critical for pole re-organization, thereby regulating whole-body regeneration. |
| DOI | 10.1016/j.ydbio.2022.04.011 |
| Alternate Journal | Dev Biol |
| PubMed ID | 35523320 |
I've bookmarked your site and am also subscribing to the RSS. I'm relieved to have found such a wealth of information on the necessary posting strategies here. I'd like to hear more about this; please do. https://basketball-stars.co/
DDX24 is a gene linked to muscle fiber organization and regulation of wound-induced Wnt activity in planarian regeneration. It likely encodes an RNA helicase enzyme. In muscle fiber organization, DDX24 plays a role in arranging muscle fibers for proper function. During planarian regeneration, it's essential for suppressing Wnt pathway activity after injury, aiding in the restoration of body polarity on https://games.lol/crafty-lands/.
Planarians are known for their regenerative abilities, and this gene's role highlights its importance in coordinating the intricate molecular processes involved in tissue regrowth and polarity re-establishment. Further research is needed to fully understand DDX24's mechanisms and implications in developmental biology and regeneration. Look it up here https://answersville.com/how-to-know-if-you-are-lactose-intolerant/.
Great information! I will visit your site more often so I am updated. The ideas I gather from here cannot be paid with money. Thanks very much! https://rainbowfriendschapter2.com/
I appreciate how the author connected the topic to current events and real-world examples. It made the article feel relevant and https://magictiles3.co/ timely.
Engage in the resolution of further puzzles in order to acquire a greater quantity of banknotes. https://skibidi-toilet.io