Department of Biotechnology
inStem (Institute for Stem Cell Science and Regenerative Medicine)

Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy.

Publication Type

Journal Article

Date of Publication

September 1, 2022

Journal

Biotechnology letters

Volume/Issue

44/9

ISSN

1573-6776

Chondroprogenitors (CPCs) have emerged as a promising cellular therapy for cartilage-related pathologies due to their inherent primed chondrogenic potential. Studies report that the addition of growth factors such as parathyroid hormone (PTH) and Bone Morphogenic Protein (BMP) enhance the chondroinducive potential in chondrocytes and mesenchymal stem cells. This study evaluated if supplementation of the standard culture medium for cell expansion with 1-34 PTH and BMP-9 would enhance the chondrogenic potential of CPCs and reduce their hypertrophic tendency.

Alternate Journal

Biotechnol Lett

PubMed ID

35920961

Authors

Kawin Padmaja
Soosai Manickam Amirtham
Grace Rebekah
Solomon Sathishkumar
Elizabeth Vinod

Keywords

Chondrogenesis
Cells, Cultured
Dietary Supplements
Growth Differentiation Factor 2
Hypertrophy
Cell Differentiation
Humans
Chondrocytes
Cartilage, Articular