Department of Biotechnology
inStem (Institute for Stem Cell Science and Regenerative Medicine)

Relax, Don’t RAN Translate It.

Publication Type

Comment

Date of Publication

December 4, 2019

Journal

Neuron

Volume/Issue

104/5

ISSN

1097-4199

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

Alternate Journal

Neuron

PubMed ID

31805259

Authors

Katherine M Wilson
Bhavana Muralidharan
Adrian M Isaacs

Keywords

Humans
C9orf72 Protein
Amyotrophic Lateral Sclerosis
Frontotemporal Dementia
CRISPR-Cas Systems
DNA Repeat Expansion
RNA Helicases
DEAD-box RNA Helicases