Department of Biotechnology
inStem (Institute for Stem Cell Science and Regenerative Medicine)

Derivation of iPSC lines from two patients with familial Alzheimer’s disease from India.

Publication Type

Journal Article

Date of Publication

January 1, 2019

Journal

Stem cell research

Volume/Issue

34

ISSN

1876-7753

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world’s aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

Alternate Journal

Stem Cell Res

PubMed ID

30605839

Authors

Ashaq H Najar
K M Sneha
Aparna Ashok
Swathy Babu
Anand G Subramaniam
Ramkrishnan Kannan
Biju Viswanath
Meera Purushottam
Mathew Varghese
Suhel Parvez
Mitradas M Panicker
Odity Mukherjee
Sanjeev Jain

Keywords

Base Sequence
Female
Humans
Induced Pluripotent Stem Cells
Cell Line
Middle Aged
India
Alzheimer Disease
Aged