Department of Biotechnology
inStem (Institute for Stem Cell Science and Regenerative Medicine)

A coumarin-nicotinic hydrazone probe for chromofluorogenic detection of toxic cyanide ions and its application in molecular logic gate and real water samples analysis.

Publication Type

Journal Article

Date of Publication

April 1, 2025

Journal

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Volume/Issue

24/4

ISSN

1474-9092

This report develops a coumarin-nicotinic hydrazide-based sensor for detection of CN ions. The ligand is prepared by simple method and has been characterized by H NMR, C NMR, FTIR, and mass spectral analyses. The sensing behavior of coumarin-nicotinic hydrazide (CNH) probe was investigated in the presence of different anions using UV-visible and fluorescence methods. The sensor showed a selective naked-eye, colorimetric, and fluorescence detection particularly in the presence of CN ions over the other anions. The sensing involves a ratiometric red shift in absorption and photoluminescence profile in presence of incremental addition of CN ions. This provides a multi-detection point at two different wavelengths. This sensor involves a displacement type approach through a nucleophilic substitution-based chemodosimeter sensor proposed based on H and C NMR along with DO exchange experiment, and mass and photophysical studies. Interestingly, the sensor affords the lowest limit of detection up to 5.97 × 10 M. The practical utility of the sensor is illustrated in molecular logic gate operation and real water analysis.

Alternate Journal

Photochem Photobiol Sci

PubMed ID

40167971

PubMed Central ID

N/A

Authors

Christopher Leslee DB
Shanmugam L
Venkatesan N
Madheswaran B
Ravula V
Karuppannan S
Kuppannan SB