inStem (Institute for Stem Cell Science and Regenerative Medicine)
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176 Articles found
Dr. Sunil Laxman receives the DBT-Wellcome Trust India Alliance Senior Research Fellowship
Blast from the Past: A Rippled Tapestry of Genetic Variation May Predispose Humans to Mental Illness
Research by scientists and clinicians from NIMHANS and the ADBS program, DBT-inStem, Bangalore, India and Tartu, Estonia underscores the fact that the common syndromes of severe mental illness, such as schizophrenia, bipolar disorder, dementia, obsessive compulsive disorder and addiction, may have an unusual evolutionary basis. The constant prevalence of mental illness, across the history of […]
Communication between Skin Epithelial Cells and Macrophages Sets Up Sterile Inflammation
Skin is the largest and the outermost organ of the body and serves as a barrier from the external environment. It has two compartments – the epidermis and dermis. The two compartments are separated by an array of extracellular matrix (ECM) components known as the basement membrane (BM). The ECM is a meshwork of macromolecules […]
TORC1 and AMPK Work Together to Manage Carbon Homeostasis in Changing Nutrient Environments
Cells naturally experience fluctuating nutrient conditions. To adapt and grow in such conditions, cells precisely balance the allocation of available nutrients through finely regulated metabolism. This regulation occurs through the functioning of nutrient responsive signaling-systems. The two important signaling complexes in all eukaryotes that regulate nutrient utilization and cell growth are target of rapamycin (TORC1) […]
One Year of the COVID Testing Centre: A Bittersweet Experience
The COVID-19 pandemic has had a devastating impact on global public health with crippling socioeconomic consequences. The goal of containing the spread of SARS-CoV-2 – the virus causing COVID-19 still relies on a comprehensive strategy of rapid testing of the virus in the population, effective treatments, and the development of therapeutics to prevent the spread […]
Robust Cell Junctions are Critical for Maintaining Stem Cell Function
The skin is the largest organ in the human body, and its outermost part, called the epidermis, is replenished every three weeks. The cells fueling this renewal of the epidermal stem cells, found in specialized areas or niche, within a region of the hair follicle (or root) is known as the ‘bulge compartment’. The bulge […]
Smell and the Immune System
Our understanding of physiological consequences to the sense of smell i.e. olfaction brought about by sensing specific environmental odours is mostly limited to animal behavioural responses. While favourable odours are thought to mediate attractive animal behaviour, aversive odours trigger escape responses. Developmental regulation of odour-sensing however, remains poorly characterized. In this regard, the importance of […]
Shared Genetic Link for Heart Muscle Disease and Diabetes Identified among South Asians
Heart failure is a leading cause of death worldwide, shown to increasingly affect young individuals below the age of 40. Cardiomyopathy is an acquired or hereditary condition of the heart muscle, eventually leading to heart failure. Recent epidemiological and clinical studies suggest that a substantial proportion of cardiomyopathy patients (around 10%) coexist with diabetes. So […]
