inStem (Institute for Stem Cell Science and Regenerative Medicine)
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178 Articles found
Mapping the unMAP’d
A team of researchers from Curie Institute, Orsay in collaboration with DBT-inStem, Bangalore report characterization of ~50 microtubule-associated proteins (called MAPs) in an unprecedented detail. Microtubules are miniature tubes like filaments in cells (microtubule diameter is 25 nanometer; 1 nanometer is one-billionth of a meter). They are important in transport of molecules within cells (Cells […]
inStem welcomes Dr Diya Binoy Joseph
Diya Binoy Joseph Fellow E (Scientist D) Dr. Diya Binoy Joseph, joins the Centre for Inflammation and Tissue Homeostasis at inStem. Diya received her B. Tech. from the National Institute of Technology, Calicut, Kerala and in 2013 she joined the Cellular and Molecular Biology PhD program at the University of Wisconsin, Madison. In 2019, she […]
Dr. Sunil Laxman receives the DBT-Wellcome Trust India Alliance Senior Research Fellowship
Blast from the Past: A Rippled Tapestry of Genetic Variation May Predispose Humans to Mental Illness
Research by scientists and clinicians from NIMHANS and the ADBS program, DBT-inStem, Bangalore, India and Tartu, Estonia underscores the fact that the common syndromes of severe mental illness, such as schizophrenia, bipolar disorder, dementia, obsessive compulsive disorder and addiction, may have an unusual evolutionary basis. The constant prevalence of mental illness, across the history of […]
Communication between Skin Epithelial Cells and Macrophages Sets Up Sterile Inflammation
Skin is the largest and the outermost organ of the body and serves as a barrier from the external environment. It has two compartments – the epidermis and dermis. The two compartments are separated by an array of extracellular matrix (ECM) components known as the basement membrane (BM). The ECM is a meshwork of macromolecules […]
TORC1 and AMPK Work Together to Manage Carbon Homeostasis in Changing Nutrient Environments
Cells naturally experience fluctuating nutrient conditions. To adapt and grow in such conditions, cells precisely balance the allocation of available nutrients through finely regulated metabolism. This regulation occurs through the functioning of nutrient responsive signaling-systems. The two important signaling complexes in all eukaryotes that regulate nutrient utilization and cell growth are target of rapamycin (TORC1) […]
One Year of the COVID Testing Centre: A Bittersweet Experience
The COVID-19 pandemic has had a devastating impact on global public health with crippling socioeconomic consequences. The goal of containing the spread of SARS-CoV-2 – the virus causing COVID-19 still relies on a comprehensive strategy of rapid testing of the virus in the population, effective treatments, and the development of therapeutics to prevent the spread […]
Robust Cell Junctions are Critical for Maintaining Stem Cell Function
The skin is the largest organ in the human body, and its outermost part, called the epidermis, is replenished every three weeks. The cells fueling this renewal of the epidermal stem cells, found in specialized areas or niche, within a region of the hair follicle (or root) is known as the ‘bulge compartment’. The bulge […]
