TitleRelax, Don't RAN Translate It.
Publication TypeJournal Article
Year of Publication2019
AuthorsWilson KM, Muralidharan B, Isaacs AM
JournalNeuron
Volume104
Issue5
Pagination827-829
Date Published2019 Dec 04
ISSN1097-4199
Abstract

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

DOI10.1016/j.neuron.2019.11.014
Alternate JournalNeuron
PubMed ID31805259