Relax, Don't RAN Translate It.
| Title | Relax, Don't RAN Translate It. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Wilson KM, Muralidharan B, Isaacs AM |
| Journal | Neuron |
| Volume | 104 |
| Issue | 5 |
| Pagination | 827-829 |
| Date Published | 2019 Dec 04 |
| ISSN | 1097-4199 |
| Abstract | The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity. |
| DOI | 10.1016/j.neuron.2019.11.014 |
| Alternate Journal | Neuron |
| PubMed ID | 31805259 |