Department of Biotechnology
inStem (Institute for Stem Cell Science and Regenerative Medicine)
Research > Research Translation

Research Patents

Innovation drives progress, and patents play a crucial role in transforming scientific discoveries into real-world applications. At inStem, pioneering research in stem cell science and regenerative medicine leads to breakthrough technologies that push the boundaries of healthcare and biotechnology.

Patents Granted

Blue fluorescent protein monomers and the uses thereof

Inventors

Ramaswamy Subramanian, Swagatha Ghosh, Wayne Ford Schaefer

Country

United States ??

Filed on

22.12.2015

Granted On

30.3.2021

Appln. No.

US62/270888/16/065,277

Compounds as fluorescent probes, synthesis and applications thereof

Inventors

Akash Gulyani, Raja SO, Sivaraman Gandhi

Country

United States ??

Filed on

13.9.2018

Granted On

20.10.2020

Appln. No.

US 16/30448

Compounds as fluorescent probes, synthesis and applications thereof

Inventors

Akash Gulyani, Raja SO, Sivaraman Gandhi

Country

India ??

Filed on

11.6.2018

Granted On

12.12.2022

Appln. No.

201841021840

A Conjugate, a composition and article, process for preparation & application thereof

Inventors

Praveen Kumar Vemula, Ketan Thorat, Sandep Chandrashekharappa, Subhashini Pandey

Country

India ??

Filed on

21.2.2018

Granted On

26.11.2021

Appln. No.

201841006678

Compositions, Materials, and Methods for deactivating toxic agents

Inventors

Praveen Kumar Vemula, Ketan Thorat, Sandep Chandrashekharappa, Subhashini Pandey

Country

Sri Lanka ??

Filed on

21.03.2019

Granted On

17.05.2023

Appln. No.

201841006678 IN (20419)

Substituted Lithocholic Acid and Methods Thereof

Inventors

Porkizhi Arjunan, Gokulnath Mahalingam, Praveen Kumar Vemula, Alok Srivastava, Srujan Marepally

Country

India ??

Filed on

29.10.2020

Granted On

2.11.2023

Appln. No.

465037

Therapeutic agents for enhancing epithelial and/or endothelial barrier function

Inventors

Vemula PK, Terrett NK, Jagadeesan S, Ravula V

Country

United States ??

Filed on

24.01.2024

Granted On

21.01.2025

Appln. No.

12,202,841 B2

Patents Filled

S.No.Appln. No.Filed onCountryTitleInventors
1PCT/
US2016/
067752
20.12.2016PCTBlue fluorescent protein monomers and the uses thereofRamaswamy Subramanian, Swagatha Ghosh, Wayne Ford Schaefer
2201741-
030084
24.8.2017IndiaCompounds targeting tandem BRCT domains of BRCA1, compositions and methods thereofVijay Potluri, Kavitha Bharatham, Ashok Venkitaraman, Gayathri Sadasivam, Jayaprakash Periasamy, Jasti Subbarao
3PCT/
IB2018/
056344
22.8.2018PCTCompounds targeting tandem BRCT domains of BRCA1, compositions and methods thereofVijay Potluri, Kavitha Bharatham, Ashok Venkitaraman, Gayathri Sadasivam, Jayaprakash Periasamy, Jasti Subbarao
462/671,73715.5.2018USASynthetic analogs of gut microbial metabolites for protection of endothelial and epithelial barriers and applications thereofPraveen Kumar Vemula, Sandeep Chandrashekharappa, Ankita A. Hiwale, Rajbir Singh, Hari Bodduluri, Venkatakrishna Rao Jala
5PCT/
IB2019/
052296
21.3.2019PCTCompositions materials & methods for deactivating toxic agentsPraveen Kumar Vemula, Ketan Thorat, Sandep Chandrashekharappa, Subhashini Pandey
618034-03
(35783.
04130)
14.5.2019PCTCompounds, compositions, methods of using and for preparing compoundsPraveen Kumar Vemula, Sandeep Chandrashekharappa, Ankita A. Hiwale, Rajbir Singh, Hari Bodduluri, Venkatakrishna Rao Jala
720191
1044840
05.11-2019IndiaDisease modifying agents, drug delivery system and method thereof for the management of osteoarthritisAmitabha Bandyopadhyay, Akrit Pran Jaswal, Praveen Kumar Vemula, Manohar Mahato
8201941
050005
04-12-2019IndiaHollow microneedle deviceKedar Ashutosh Badnikar, Shreyas Nataraja Jayadevi, Suman Pahal, Ashish Dhayani, Praveen Kumar Vemula, Joseph Mathew,
Manjunatha Manglore Nayak, Dinesh Narasimhaiah Subramanyam
9TEMP/E-1/
10879/
2020-CHE
09.03.2020IndiaCompact liposomal vehicle for delivery of large moleculesSrujan Marepally, Saravanabhavan Thangavel, Alok Srivastava (CSCR)
1020204
1014818
03.04.2020IndiaMicrotubule markerMinhajuddin Sirajuddin, Balaji M Rao, Shubham Kesarwani
112020/inStem
-KHK/01
12.04.2020IndiaGermicidal fabric technology to create antiviral/antibacterial masks, PPEs and clothsPraveen Kumar Vemula, Mahendra K Mohan, Sandeep Chandrashekharappa, Siju C.
12TEMP/E-1/
21886/2020-
CHE or 20204
1020165
13.05.2020IndiaCompositions and methods for reactivating developmentally silent genesMohankumar Murugesan,  Alok Srivastava (CSCR)
1320204
1030231
15.07.2020IndiaA biosensor, a kit and application thereofArati Ramesh, Akash Gulyani, Geen George, Siladitya Bandyopadyay, Sreesa Sreedharan, Anirudh Chakravarhy Srinath
1420202
1051801
27.11.2020IndiaMethods and systems for determining viruses in biological samples using a single round based poolingManoj Gopalkrishnan, Ajith Rajwade, Dasaradhi Palakodeti and Sandeep Krishna
15IN 20214
1000921
08.01.2021India A cocktail Formulation for Selective Enrichment of Gene Modified CellsSaravanabhavan Thangavel, Srujan Marepally, Alok Srivastava
16202141
001050
09.01.2021IndiaRecombinant Milk ProteinsS. Ramaswamy, Sanchari Banerjee and Kanaga Vijayan
17PCT/
IB2021/
053780
05.05.2021PCTDisease modifying agents, drug delivery system and method thereof for the management of osteoarthritisAkrit Pran Jaswal, Amitabha Bandyopadhyay, Praveen Kumar Vemula, Manohar Mahato, Bhupendra Kumar
1820214
1029243
29.06.2021IndiaMolecular markers for infection-induced lung damageNeha Vyas (St. John’s Research Institute) and Apurva Sarin (inStem)
1920214
1033290
23.07.2021IndiaFormulation, Lipid Compounds And Methods ThereofSrujan Marepally, Alok Srivastava
20PCT/
IN2022/
050017
07.01.2022PCT A cocktail Formulation for Selective Enrichment of Gene Modified CellsSaravanabhavan Thangavel, Srujan Marepally, Alok Srivastava
21202241
006792
08.02.2022IndiaSingle-step molding process for fabrication of hollow microneedle arrayGhate V, Renijith A, Badnikar KA, Nataraja Jayadevi S, Pahal S, Vemula PK, Nayak MM, Narasimhaiah Subramanyam D.
2220224
1014827
17.03.2022IndiaCompositions and methods to enhance the quality and shelf-life of biological materialsPraveen Kumar Vemula, Manohar Mahato, Subhashini Pandey, Preethem Srinath, Utkarsh Bhutani
2320224
1030885
30.05.2022IndiaA method for modification of ß-globin geneMohankumar K. Murugesan, Alok Srivastava, Kirti Prasad
2420224
1030465
27.05.2022IndiaA method for reactivation of fetal hemoglobin and a composition thereofSaravanabhavan Thangavel, Alok Srivastava
25PCT/
IN2022/
050660
22.07. 2022IndiaFormulations, Lipid compound, methods and there ofSrujan Marepally, Alok Srivastava
26202241
045242
8.08.2022IndiaA method for downregulation of a Target Gene and a composition there off.Shaji R Velayudhan, Alok Srivastava, Mohankumar K. Murugesan
27202211
048425
25.08.2022IndiaProducts and compositions for the treatment of viral infections.Colin Jamora,Tanay Bhatt,Amitabha Majumdar, Naresh Ghatlia.
28202241
055876
29.09.2022IndiaMethod for elevation of Gamma GlobinMohankumar K. Murugesan, Alok Srivastava, Nivedhitha D, Vignesh R. A
2963/
251,229
01.10.2022USACompositions and methods for treating a b-Thalassemia DiseaseDavid I.K. Martin, Mark DeWitt, Mark C. Walters, Wendy J. Magis, Saravanabhavan  Thangavel and Dario Boffelli
3063/
419,015
25.10.2022USATherapeutic agents for enhancing epithelial and/or endothelial barrier functionPraveen Kumar Vemula, Nicholas Kenneth Terrett, Sakthimala Jagadeesan, Venkatesh Ravula
31PCT/
IB2022/
061996
9.12.2022PCTCitric acid cycle and lactate transport inhibitors for prevention and/or treatment of skin disordersSrikala Raghavan, Uttkarsh Ayyangar.
32PCT/
IB2023/
052628
17.3.2023PCTScaffolds for selective scavenging of storage lesion from biological material and methods thereofPraveen Kumar Vemula, Manohar Mahato, Subhashini Pandey, Preethem Srinath, Utkarsh Bhutani
33PCT/
IN2023/
050806
25.08.2023PCTProducts and compositions for the treatment of viral infections.Colin Jamora,Tanay Bhatt,Amitabha Majumdar, Naresh Ghatlia.
34202241
055876
29.09.2023IndiaA method for elevation of Gamma GlobinMohankumar K. Murugesan, Alok Srivastava, Nivedhitha D
35PCT/
US2023/
077699
25.10.2023PCTTherapeutic agents for enhancing epithelial and/or endothelial barrier functionPraveen Kumar Vemula, Nicholas Kenneth Terrett, Sakthimala Jagadeesan, Venkatesh Ravula
36202341
082277
04.12.2023IndiaStrategies for Precision Editing of Homologous RegionsMohankumar K. Murugesan Anila George, Nithin Sam Ravi, Kriti Prasad, Alok Srivastava
37202341
082821
05.12.2023IndiaA Method for Gene Modifiction within the Intron1 Region of Gammma GlobinMohankumar K. Uruguayan , Anila George , Alok Srivastava
38PCT/
IN2024/
050221
01.03.2024EUA Nucleo-Cytoplasmic Form of Protein Lysine Methyltransferase EHMT1N/C Methods and Use there of Shravanti Rampalli Deshpande,Kriti Kestur Biligiri
39202441
056626
25.07.2024IndiaExtracellular vesicles and uses thereof for targeted deliveryThangavel S, Karuppusamy K, Murugesan R, Ariudainambi K and Kumar A
40202441
063092
21.08.2024IndiaGene editing for hemoglobinopathiesThangavel S, Chandraprabha P, Azhagiri M
41202441
072108
24.09.2024IndiaEnhanced gene reactivation via targeted promoter editingMohankumar KM, Nivedhitha Devaraj, Nithin Sam
42PCT/
IN2024/
052329
03.12.2024PCTStrategies for precision editing of homologous regionsMohankumar KM, Anila George, Nithin Sam Ravi, Kriti Prasad, Alok Srivastava