Lung

Gulami I, Jaya-Sundar T, Chhajed P, Chavda S, Guha A*. Autocrine TGF-beta signalling actively controls the senescence phenotype. Manuscript in preparation.

Deshpande A, Prabantu VM, Lingamallu S, Keerthana B, Wadate A, Naveenkumar CN, Bharatkumar K, RK Shandil, Narayananan S, Taketo MM, Hagood J, Dong, H, Lafkas D, Guha A*. β-catenin establishes competence for alveolar regeneration in distal airway progenitors. Manuscript in revision

Joy N, Deshpande A, Lingamallu S, Prabantu VM, Naveenkumar CN, Bharathkumar K, Bhat S, Alvarado-Martinez Z, Livraghi-Butrico A, Hagood J, Boucher R, Lafkas D, Byrd K, Narayanan S, Shandil RK, Guha A*. Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung. Life Science Alliance DOI: 10.26508/lsa.202503268 (2026)

Lingamallu S, Deshpande A, Joy N, Ganesan Ray N, Ladher R, Taketo MM, Lafkas D, Guha A* et al. Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition. Cell Reports 43, 114654 (2024)

Sain Basu D, Bhavsar R, Gulami I, Lingamallu S, Muddashetty R, Veeranna C, Chagarji S, Thimmulappa R, Bhattacharya A, Guha A*. The Fragile X Mental Retardation Protein (FMRP) protects the lung from xenobiotic stress by facilitating the Integrated Stress Response. J Cell Sci 135 (9): jcs260033 (2022)

Prabhakara C, Godbole R, Sil P, Jahnavi S, van Zanten T, Sheth D, Subhash N, Chandra a, Nuthakki VK, Puthiyapurayil TP, Ahmed R, Najar A, Lingamallu S, Das S, Mahajan B, Vemula P, Bharate S, Singh PP, Vishwakarma R, Guha A, Sundaramurthy V* and Mayor S* (2021). Niclosamide inhibits SARStiCoV2 entry by blocking internalization through pH-dependent CLIC/GEEC endocytic pathway. PLoS Pathog Jul 12;17(7):e1009706 (2021).

Guha A*, Deshpande A, Jain A, Sebastiani P, Cardoso WV*. Uroplakin 3a+ cells are a distinctive population of epithelial progenitors that contribute to airway maintenance and post-injury repair. Cell Reports Apr 11:19, 246-254 (2017).

Guha A*,Vasconcelos M, Rui Z, Gower A, Rajagopal J, Cardoso WV*. Analysis of Notch signaling-dependent gene expression in the developing airways reveals diversity of Clara cells. PLoS One 9(2):e88848 (2014).

Guha A*, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Dickel L, Kimura S, Johnson J, Gao J, McMahon J, McMahon A, and Cardoso WV*. Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc. Natl. Acad. Sci., USA Jul13; 109 (31): 12592-97 (2012)

Drosophila Trachea

Chhajed P, Prabantu VM, Guha A*. ATR/Chk1-dependent control of Cdc25/String regulates growth of postmitotic polyploid cells in airways of the Drosophila larva. Manuscript in preparation.

Kizhedathu A, Chhajed P, Sain-Basu D, Lahari Y, Mukherjee T, Vinothkumar KR, Guha A*. Duox1-generated reactive oxygen species activate ATR (mei41)/Chk1(grapes)-dependent G2 arrest in tracheoblasts in Drosophila. eLife 10:e68636 (2021).

Kizhedathu A, Kunnappallil R, Bagul A, Verma P and Guha A* Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts. eLife 9:e57056 (2020).

Kizhedathu A, Bagul A, and Guha A*. Negative regulation of G2-M by ATR (mei41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila. eLife 7:e29988 (2018).

Rao PR, Lin L, Huang, H., Guha A, Roy, SR Kornberg TB*. Developmental compartments in the larval trachea of Drosophila. eLife 10.7554 (2015).

Guha A, Lin L, Kornberg TB. Organ renewal in Drosophila by differentiated cells that restart a mitotic program. Proc. Natl. Acad. Sci., USA Aug 5; 105(31):10832-6 (2008).