i-DHANS: Indian database of healthy aging nucleotide sequences
Manuscript under preparation
Indian database of healthy aging nucleotide sequences (i-DHANS) is the first Indian exome database for healthy aging individuals. It provides comprehensive information of different types of genetic variation on the Indian aging alleles that help to distinguish disease associated mutations. A total of 1500 control participants were analyzed and 94 healthy aging individuals were selected with the mean age of 80 years without any medications. These subjects were tested clinically negative for the following: (a) Infection (b) Cardiovascular disease (c) Hypertension (d) Diabetes mellitus (e) Cancer (f) Brain-related disorders. i-DHANs offers a number of potential advantages over already available data sources and addresses the unidentified gaps by providing genetic dataset of healthy aging individual. This might provide new insights in comparing and filtering genetic markers for different diseases and addressing the most important aspect of understanding the genetics of healthy aging Indian.
This study is partially funded by Wellcome Trust/DBT India Alliance.