ABCC6


Gene name
ABCC6
Protein
Multidrug resistance-associated protein 6 (ATP-binding cassette sub-family C member 6) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E)
Ensemble ID
ENSG00000091262
Uniprot IDs
O95255
Gene Synonyms
ARA   MRP6  
MGI ID
MGI:1351634
NCBI ID
105369239
Function
Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). {ECO:0000269|PubMed:11880368}.; FUNCTION: Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}.
Expression
Expression Atlas
Chromosome Name Start BP End BP Gene Details Protein Details
16 16148928 16223522 ENSG00000091262 O95255