%0 Journal Article %J Neuron %D 2019 %T Relax, Don't RAN Translate It. %A Wilson, Katherine M %A Muralidharan, Bhavana %A Isaacs, Adrian M %X

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

%B Neuron %V 104 %P 827-829 %8 2019 Dec 04 %G eng %N 5 %R 10.1016/j.neuron.2019.11.014