TY - JOUR T1 - Relax, Don't RAN Translate It. JF - Neuron Y1 - 2019 A1 - Wilson, Katherine M A1 - Muralidharan, Bhavana A1 - Isaacs, Adrian M AB -

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

VL - 104 IS - 5 ER -