Dr. Dhandapany Perundurai - vivo
Objectives: Our group is involved in the following tasks:
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Next generation sequencing (NGS) to identify novel genes for cardiomyopathies
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An in vivo large- scale small molecules screening using Drosophila model
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We have generated multiple lines of transgenic Drosophila model with sarcomeric gene mutations respectively, which specifically display myopathy in Drosophila. In this objective, we will use these flies as a whole animal model and screen with 2000 FDA approved compounds. In addition, we will explore the molecular mechanisms of these drugs in rescuing cardiomyopathy.
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