Objectives: Our group is involved in the following tasks:

  1. Next generation sequencing (NGS) to identify novel genes for cardiomyopathies

    • We have recently organized fifty unrelated Indian cardiomyopathy index patients and their family members (a total of 90 participants) for our genetic studies. We are performing whole exome sequencing in 60 selected participants (30 index patients and their 30 unaffected family members respectively as an internal controls).
    • Functional characterization of the novel genes will be performed using cellular models.

  2. Functional characterization of cardiomyopathies using patient specific induced pluripotent stem cells (hiPSCs)

  3. An in vivo large- scale small molecules screening using Drosophila model

  4. Humanized transgenic mouse model of cardiomyopathy

  5. Role of RAF1 in cancer and cardiomyopathy

Faculty