@article {2062,
	title = {The Aging Metabolome-Biomarkers to Hub Metabolites.},
	journal = {Proteomics},
	volume = {20},
	year = {2020},
	month = {2020 03},
	pages = {e1800407},
	abstract = {<p>Aging biology is intimately associated with dysregulated metabolism, which is one of the hallmarks of aging. Aging-related pathways such as mTOR and AMPK, which are major targets of anti-aging interventions including rapamcyin, metformin, and exercise, either directly regulate or intersect with metabolic pathways. In this review, numerous candidate bio-markers of aging that have emerged using metabolomics are outlined. Metabolomics studies also reveal that not all metabolites are created equally. A set of core "hub" metabolites are emerging as central mediators of aging. The hub metabolites reviewed here are nicotinamide adenine dinucleotide, reduced nicotinamide dinucleotide phosphate, α-ketoglutarate, and β-hydroxybutyrate. These "hub" metabolites have signaling and epigenetic roles along with their canonical roles as co-factors or intermediates of carbon metabolism. Together these hub metabolites suggest a central role of the TCA cycle in signaling and metabolic dysregulation associated with aging.</p>
},
	issn = {1615-9861},
	doi = {10.1002/pmic.201800407},
	author = {Sharma, Rishi and Ramanathan, Arvind}
}
