We are seeking highly motivated postdoctoral fellows interested in the area of epigenetics and human stem cell biology. Available projects involve deciphering the role of chromatin modulators in lineage specification (hematopoietic and neural lineages)using human pluripotent cells, as well as the application of functional genomic approaches to our areas of interest.
Candidates must have a Ph.D. and/or M.D. with prior experience in ES/iPSC culturing, differentiation flow-cytometry and microscopy techniques are encouraged to apply.
If interested, please send a CV, a brief statement detailing your reasons for interest in the position and your career goals, and contact information for references to at shravantidr AT instem dot res dot in
At present a postdoctoral position is available in the field of hydrogels, self-assembled or polymer based, for biomedical applications.
The Vemula Lab - http://praveenlab.net/openings.html - is focused in translational research where novel concepts/approaches/biomaterials are being developed for solving unmet clinical needs. We have a vibrant group of people working together to solve biomedical problems.
We are looking for innovative and motivated people who are passionate about translational research and have strong experience in synthesis & characterisation of hydrogels and organic synthesis and drug delivery.
Required Qualification: Ph.D. in Chemistry/Materials Science
Applications are invited from creative, self-motivated and experienced SENIOR SCIENTISTS with a track record of excellence at the forefront of drug discovery research in academia or industry for the position of ‘Staff Scientist’ in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research programme in a new initiative for chemical biology and therapeutics research.
The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, between the National Centre for Biological Sciences (NCBS) and the Institute for Stem Cell Biology and Regenerative Medicine (inStem). (http://instem.res.in/research/research-themes/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem/NCBS) coordinates the programme.
The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia. Thus, we are looking to recruit senior scientists with relevant postdoctoral experience of directing lead generation and target validation projects in a multidisciplinary team environment using functional reporting. A high level of expertise in any one of the following broad areas - molecular cell biology and/or protein biochemistry and structural biology and/or computational or synthetic chemistry - is required, along with sufficient familiarity of the other disciplines to permit the applicant to lead a multidisciplinary project. Applicants with experience in industry or in academic drug discovery programmes are particularly welcome.
Candidates must have a Ph.D. in a relevant subject, and several years’ relevant postdoctoral experience, ideally gained in pharma or biotech. A track record of accomplishment in drug discovery, ideally using structure-guided approaches, is essential, as is experienced in project management. Evidence of working with a high level of independence to deliver scientific projects ‘on time and to budget’ would be an advantage.
Qualifications and experience
InStem is highly collaborative and intellectually stimulating environment that provides world-class facilities. InStem shares the campus and has extensive collaborations with NCBS, a premier research institute in India. C-CAMP is a new research institute in the same campus, which also provides high-end platform services. Currently, InStem is expanding its post-doctoral program to bring bright young scientists into this vibrant atmosphere.
The lab works on two broad themes. One of the interests is to map the gene regulatory circuits controlling lineage-specification in early vertebrate mesoderm. Systematic genome –scale approaches such as ChIP-sequencing for key transcription factors in combination with mouse genetics studies will be carried out towards this goal. This study would also require bio-informatics expertise. Another major interest in the lab is in understanding vertebrate head evolution. Particularly, we aim to investigate the mechanistic basis for the emergence of novel embryonic cell types that are central to head evolution. Initially, this study would employ mouse genetic studies and possibly, a high-throughput RNAi screen to determine the regulatory network that underlie evolution of novel cell types. For more details, click here.
Candidates with experience / expertise in mouse genetics and / or ChIP-sequencing approaches will be favored.
Contact: Dr. Ramkumar Sambasivan – ramkumars at instem.res.in
We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. This would be a perfect opportunity for EITHER biology graduates who have an interest in building fluorescent biosensors and imaging OR chemistry graduates who are interested in various chemical biology and protein engineering approaches for biosensing. Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will also be opportunities to collaborate with other outstanding groups at inStem and NCBS in epithelial and adhesion biology, technology development and stem cell biology.
We are looking for
We are a new lab and are looking for people who are very motivated and want to have fun looking to find new ways of doing biology. Kindly apply with CV and full contact details of two referees to akashg at instem dot res dot in
We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. We will also be building new biosensors for addressing signaling dynamics in stem cells in collaboration with other groups at inStem. We are looking for outstanding chemists who have a flair for adapting cutting edge chemical approaches for cell biology. Experience in dye chemistry, fluorescence spectroscopy and chemical biology will be highly desirable. Interest in quantitative approaches and fluorescence microscopy will be a plus.
Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will be ample opportunities to collaborate with other groups at inStem and NCBS for both technology/tool development as well to address fundamental questions in stem cell biology.
Kindly apply with CV and full contact details to akashg at instem dot res dot in.
To design, establish and run a professionally managed animal facility with a team of experts working under the director.
To oversee multiple teams - transgenic, veterinarian, and colony maintenance.
To network and integrate with international animal facilities and experts for continuous growth of the facility to make the facility world class.
To implement a management plan that includes allocating space and best practice for animal welfare
To analyze requests for genetic manipulations for relevance and avoid redundancy
To establish/enforce policies for compliance with relevant oversight agencies to ensure program accreditation
Ph.D. Degree in relevant field
Managerial and team leadership experience, with animal facility supervisory work preferred
Extensive knowledge of transgenic/gene targeting technologies, ES isolation, culture and analysis, cryopreservation and recovery of embryos and sperm, molecular biology, and animal husbandry
Exceptional interpersonal skills
Prior international networking experience to establish collaborations and utilize existing consortia.
Detailed familiarity with animal welfare regulation
Applicants can be of any nationality
Languages: English both spoken and written is essential.
Tenure: This position is initially for three years, extendable to five based on requirements and performance. Subsequent terms will be for five years with annual reviews.
This package must include:
Up-to-date CV with names and contact details of three referees
Brief description of your skills that are relevant to the position of director
Applications will be accepted until the position is filled by a suitable candidate. Please note that only short listed candidates will be notified.
Institute for Stem Cell Biology and Regenerative Medicine (inStem) is an autonomous institution under the aegis of Department of Biotechnology, Government of India. inStem(www.instem.res.in) along with National Centre for Biological Sciences (NCBS) & Centre for Cellular & Molecular Platforms (C-CAMP) forms the Bangalore Bio-Cluster. inStem is looking for appointment of a Chief Administrative Officer(CAO) to head its administrative & financial functions. The incumbent shall be a self-driven individual who is highly motivated team player capable of managing all aspects of administration, finance and accounts including externally funded projects. The incumbent shall be the highest-ranking administrative officer reporting to Dean & Director. Currently, inStem receives around Rs. 100 Crores of funding which is likely to increase in the next two years. It is essential that the incumbent is a well-organized individual with excellent communication and multi-tasking skills who thrives on diversity in an evolving professional environment.
JOB TITLE: Chief Administrative Officer
Job Profile: The incumbent shall be responsible for running a proactive responsive administrative & financial system based on the policy guidelines set up by the inStem Governing Council. The incumbent is expected to be a person with a positive attitude and capacity for problem resolution. Further, it is expected that the candidate should have proven ability to co-ordinate and lead a team of officers from various wings e.g. administration, finance & accounts, purchase & stores, hospitality & security of large academic / R &D institution.
At an appropriate point, the incumbent may be considered for entrusting the responsibility of overseeing the management functions of the cluster institutions.
Graduate/Post-Graduate degree from a recognized university.
Excellent communication and presentation skills.
Working in an IT enabled/computerized environment using ERP tools.
(1) Post-graduate Degree or Diploma in Accounting/ Company Law/ Finance/ Business Management from a recognized institution
ESSENTIAL: At least 15-20 years as outlined in the job profile above with a basic knowledge of finance and accounts.
1. Experience of handling matters relating to purchase & stores, personnel management, contract for outsourced services.
2. Scrutiny, evaluation and finalization of tender documents and works bills.
3. Experience of working in an academic and/or research organization of repute.
Candidates having outstanding record of accomplishment with 10-15 years of experience may also apply. They may be considered for an appropriate position with the possibility of upward progression in future.
AGE LIMIT: Below Fifty Five (55) years.
SALARY: Depending upon the qualification & experience, salary shall be fixed in Pay Band No 3 or 4 with appropriate Grade Pay. Salary will not be a constraint for outstanding candidates with proven record of accomplishment and experience in multiple areas of administration.
NATURE OF APPOINTMENT: On Five (5) year contract of which the First (1st) year shall be on probation. Renewal upto 5 years and long term appointment thereafter subject to review of performance.
HOW TO APPLY: Interestedcandidates may send in their application with Curriculum Vitae (CV) by email in the prescribed format given below along with names and addresses (email & postal) of three (3) referees of which one has to be the immediate reporting officer. Candidates already in employment in Government, Public Sector Units & Autonomous Bodies must attach No Objection Certificate (NOC) from their employer. NO PAPER APPLICATIONS will be accepted.
1. Full Name 2. Address for Correspondence 3. Permanent Address 4. Nationality 5. Date of Birth 6. Whether belonging to SC/ST/OBC if so, give details and attach Caste/Tribe/OBC (non-creamy layer certificate from the competent authority) 7. Educational Qualifications with complete details 8. Experience with complete details 9. Names, Addresses, Telephone Numbers, Fax Number and Email Address of three Professional Referees (one must be a Direct Supervisor) who have supervised work in the recent past. 10. Scale of pay and Basic pay drawn with details of allowances 11. Any other relevant information.
inStem reserves the right to fill or not to fill the post advertised. Only candidates called for interview will be informed of the result and no interim correspondence shall be entertained.