Open Positions

NOMINATIONS/APPLICATIONS FOR THE POST OF DIRECTOR, inStem, Bangalore

DEPARTMENT OF BIOTECHNOLOGY
MINISTRY OF SCIENCE & TECHNOLOGY, GOVERNMENT OF INDIA
NOMINATIONS/APPLICATIONS FOR THE POST OF DIRECTOR, inStem, Bangalore

Nominations/Applications are invited for the post of Director on deputation (including short term contract), Institute for Stem Cell Biology and Regenerative Medicine (inStem) [www.instem.res.in],Bangalore, an autonomous Institute under the Department of Biotechnology, Government of India [www.dbtindia.nic.in].
The Institute for Stem Cell Biology and Regenerative Medicine (inStem), is a state-of-the-art research institute in Bangalore, dedicated to the study of stem cell and regenerative biology. In-Stem emphasizes collaborative research in stem cell biology. inStem’s mandate to allow this cross-disciplinary, multi-pronged approach to research, straddles the divide between clinical and laboratory research in stem cell biology. In trying to answer intractable and challenging questions that face the field, inStem seeks to rewrite the paradigm of the research institute: without barriers and across disciplines.
The applicants should be below
56 years of age. The post carries of Pay Scale of Rs.80000 (Fixed) with usual allowances as per the Govt. of India Rules.
Those applicants from Central/ State Governments,
research institutes, autonomous bodies etc. are typically expected to be:-

  1. Holding analogous post or post in HAG + Scale on regular basis in the parent Department.

  2. 3 Years service in PB-IV with Grade Pay of Rs.10,000/- ; or

  3. 5 years service in PB-IV with Grade Pay of Rs.8900/- ; or

  4. 7 years service in PB-IV with Grade Pay of Rs.8700/-

Essential

  1. Ph.D in Life Sciences or other Allied Sciences / Engineering or M.D. or equivalent

  2. Relevant experience in the area of organismal, cellular, molecular, systems biology, or biotechnology, and

  3. Excellent track record, proven expertise of guiding research activities in the area of specialization. Experience in Science – administration will be an asset.

N.B : The Search-cum-Selection Committee is empowered to consider / nominate persons of capability and eminence with lesser experience and younger in age to be appointed as Director, inStem, Bangalore on pay scale / emoluments negotiable in the process.

The period of deputation includes period of deputation in other ex-cadre posts, held immediately preceding this appointment in the same or some other organization /Department should ordinarily not exceed 5 years. The maximum age limit for appointment on deputation should not exceed 56 years as on the closing date of receipt of nominations / applications.

The nomination / application along with detailed curriculum vitae including the date of birth, address for correspondence including telephone no., fax and e-mail address, qualifications acquired, professional and research experience, present position and scale of pay with total emoluments, publication details and a 500 words write-up on the candidate’s vision of inStem, Bangalore for the next ten years may be sent to Smt. Kusum Lata Sharma, Deputy Secretary, Department of Biotechnology, Block-2, CGO Complex, Lodi Road, New Delhi-110 003, superscribing the cover“Nomination / Application for the Post of Director, inStem” so as to reach her within 30 days from the date of publication of this advertisement. The detailed advertisement and format of application is available at DBT Website www.dbtindia.nic.in and at the inStem Website www.instem.res.in

Download Application Format

The Department reserves the right to relax any of the requirements prescribed above.

Academic/Scientific Positions

A JRF position available in Stem Cell Facility.

A Junior Research Fellow position is available in the Stem Cell Facility in inStem from January 1st 2015.

You will join the project to generate human ESC/iPSC expressing fluorescence tagged proteins. You will also have a duty to operate/maintain the Facility at the high quality standard.

Applicants should have experience in basic molecular biology techniques including cloning, DNA/RNA isolation, and PCR and mammalian cell culture techniques. Please send your CV and the names and e-mail addresses of at least two references to Dr. Murata-Hori.
( This email address is being protected from spambots. You need JavaScript enabled to view it. )

Postdoctoral positions available in the area of lipid synthesis and gene transfection.

A position for a Postdoctoral fellow is available in Praveen Vemula's lab (www.praveenlab.net) in the area of lipid synthesis and gene transfection. The Institute for Stem Cell Biology and Regenerative Medicine (inStem) is a highly collaborative environment.

At present we are looking for an oustanding postdoctoral candidate with experience in the area of lipid synthesis and gene transfection. Experience in organic synthesis, fabrication and characterisation of self-assembled materials is required.  We provide an opportunity to mentor young researchers that could be stepping stone for your next career move. Motivated candidates can send their CV and research summary to Praveen Vemula ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) and the position will remain open until filled.

Postdoctoral positions available in Bioinformatics and Genomics.

A position for a Postdoctoral fellow is available in the area of bioinformatics and genomics. The Institute for Stem Cell Biology and Regenerative Medicine (inStem) is a highly collaborative environment and we are seeking an individual who can interface with both wet and dry lab scientists to use profiling technologies to advance our understanding of tissue regeneration and repair.  Consequently, the selected candidate for this position can expect world-class training in integrating the fields of cell biology, molecular biology, animal models, and genomics/proteomics.

We are seeking an individual with expertise in analyzing next generation sequencing data, mutation calling in exome seq data, network inference, data integration, and modeling.  Competitive candidates would also have programming experience in scripting languages with perl, C, C++, and R programming.  This position requires a PhD in Computational Biology, Bioinformatics, Biostatistics or related fields, and evidence of scientific productivity through publications in international journals.  Motivation to gain an in-depth understanding of biological phenomena is required!  Applications should include a current CV and names of at least three references.  Application packages and inquiries regarding this position can be sent to Dr. Dasaradhi Palakodeti ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) or Dr. Colin Jamora ( This email address is being protected from spambots. You need JavaScript enabled to view it. ).  Screening of applications will commence immediately and the position will remain open until filled.

Postdoctoral positions available in computational and experimental neuroscience.

We offer two Postdoctoral positions in computational and experimental neuroscience, as part of a collaboration between Matt Nolan (University of Edinburgh) and Upi Bhalla (National Centre for Biological Sciences, Bangalore). The projects are to examine representations, connectivity and plasticity in the Hippocampal-Entorhinal circuitry.

One position is for a computational analysis of representations, sequence formation and plasticity.
The other position is more experimental, and will involve patch, tetrode, and 2-photon recordings in mice as they learn representations and associations.

Interested individuals are encouraged to visit the CBDR (http://instem.res.in/wadhwani-center/center-for-brain-development-and-repair) website for more information and to contact

Upi Bhalla
Mail :( This email address is being protected from spambots. You need JavaScript enabled to view it. )
Lab: http://www.ncbs.res.in/bhalla

  or

Matt Nolan directly for more information.
Mail: ( This email address is being protected from spambots. You need JavaScript enabled to view it. )
Lab: http://nolanlab.mvm.ed.ac.uk/

Requirements:-

A 2-page CV, 1-page statement of future work and how it fits in with the aims of CBDR and the names of three referees should be sent to the Centre Administrator, Claudia Pisani ( This email address is being protected from spambots. You need JavaScript enabled to view it. ).

Postdoctoral Position is available in Dr. Raghavan's Lab

 

The primary interest of the Raghavan lab is to elucidate how epithelial homeostasis is maintained in development and perturbed in disease states. We use the mammalian skin as a model system to address these questions.

Postdoctoral positions are immediately in the following areas

  1. Role of micro-RNA’s and other small RNA’s in maintenance of epithelial stem cell homeostasis.
  2. Role of RNA binding proteins in maintaining cell-substratum adhesion.

Specific areas of interest include cell biology, signal transduction, molecular biology and protein biochemistry. Applicants should have a Ph.D. with a strong background in cell biology and biochemistry and excellent written and oral communication skills. Experience working with mouse model systems and using retro/lenti viral vectors will be considered favorably.

More information on the research interests of the lab can be found here http://instem.res.in/2012-10-03-06-57-14/srikala-raghavan

Interested applicants should send their application and names and addresses of three referees to This email address is being protected from spambots. You need JavaScript enabled to view it.

 

CENTRE FOR BRAIN DEVELOPMENT AND REPAIR

Advertisement No. 4/2014

CHIEF TECHNOLOGIST/TECHNICAL MANAGER/PROGRAM MANAGER

Applications are invited from qualified, creative, self-motivated scientists for “Chief Technologist/ Technical Manager/Program Manager” positions in the “Centre for Brain Development and Repair’’ project funded by the Government of India, Department of Biotechnology:

The Institute for Stem Cell Biology and Regenerative Medicine (inStem), in partnership with the National Centre for Biological Sciences (NCBS) (http://www.ncbs.res.in) and the University of Edinburgh, has established the Centre for Brain Development and Repair (CBDR) at the NCBS/inStem campus in Bangalore, India. CBDR’s mission is to understand the cellular, physiological and behaviour basis for Developmental and Degenerative Brain Disorders with an initial focus on Autism Spectrum Disorders and Intellectual Disability.

We are recruiting experienced scientists, preferably with technical and managerial expertise to be managers of each of the following integrated research fields:

1) disease modelling using human pluripotent stem cells, 2) novel rodent behavioural paradigms, 3) in vivo and in vitro electrophysiology and imaging and 4) synaptic and circuit modelling.

The prescribed qualification/experience is Ph.D or Masters in Engineering along with appropriate research experience. Salary and benefits will be attractive and will be commensurate with qualification/experience and suitability for the post/performance in the interview.

Appointments to these posts are made for one year at a time, and renewed subject to review. Those selected will be part of a well-funded, highly collaborative team of researchers working in state-of-the-art facilities. Age will not be a bar for outstanding candidates.

Please visit http://instem.res.in/careers/open-positions for full advertisement. This advertisement will be kept as a rolling advertisement on the inStem website, and those interested may apply even after the last date indicated below. Such applications received after the due date indicated below also will be periodically reviewed.

HOW TO APPLY:

Applicants are encouraged to contact the Director of CBDR, Professor Sumantra Chattarji ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) and the Associate Directors Professor Siddharthan Chandran ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) and Professor Peter Kind ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) with details of their area of work and interest and to send in the following information by email to This email address is being protected from spambots. You need JavaScript enabled to view it.

  • Curriculum Vitae (CV)

  • Publication List

  • Contact details of three professional referees.

NO PAPER APPLICATION will be accepted.

Applications received upto 2nd May 2014 will be considered in the first lot and those received thereafter will be reviewed periodically and screening/ selection taken up as appropriate.

InStem reserves the right to fill or not to fill the posts advertised.

CENTRE FOR CHEMICAL BIOLOGY & THERAPEUTICS

Advertisement No. 3/2014

Applications are invited from qualified, creative, self-motivated scientists for several positions in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research program in a new initiative for chemical biology and therapeutics research. The program is coordinated by Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem)

The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) and the University of Cambridge (http://instem.res.in/research/research-themes/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus (http://www.ncbs.res.in) in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia.

The prescribed qualification/experience for Senior Scientists is Ph.D. with 2-4 years of Post-doctoral experience in the relevant area and for Associates it is Master’s/Bachelor’s degree with 1-3 years experience of Academic or Industrial work experience.

Age will not be bar for candidates with exceptional experience in the specific field. Outstanding young Ph.D.s are also encouraged to apply for Senior Scientist positions.

Salary and benefits will be attractive and will be commensurate with qualification/experience and performance in the interview.

Appointments to these posts are made for one year and extended thereafter based on performance of the candidate during the course of the CCBT project.

Name of the post and qualification/experience for each one are indicated below -

SENIOR SCIENTIST – HTS AUTOMATION BIOLOGIST

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • PhD in Molecular Biology/Cell Biology/Biochemistry

  • 2-4 yrs of experience in assay design, execution and screening

  • Previous experience in using liquid handling stations, implementing high content screens, automated microscopy and managing large data sets are encouraged to apply

JOB DESCRIPTION

In this position you will support chemical biology efforts underpinning new lead discovery by providing high throughput biology expertise including, but not limited to the following;

  • Develop, optimize and validate biological assays amenable to automation and high throughput screening

  • Automate high throughput screening assays to support lead discovery programs

  • Perform primary high throughput screening, secondary hit profiling assays, and focused small molecule screens

  • Program and operate custom-integrated automation systems, prepare assay reagents and execute assays

  • Perform data analysis, reporting and integration with database software

  • Interact with multidisciplinary project teams for lead discovery

  • Participate in project team meeting and contribute to the projects intellectually and communicate data

ESSENTIAL DUTIES AND JOB FUNCTIONS

  • Specific experience with high throughput screening and assay development

  • Experience in biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP, alpha screen, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies

  • Solid understanding of modern high throughput screening assay technologies

  • Specific experience using laboratory automation equipment

  • Excellent computer skills with experience in data analysis

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment and managerial experience of junior scientists

HTS TECHNOLOGY ASSOCIATE

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • Master's degree in discipline of life sciences with 1-3 years of work experience

  • Substantial experience in high throughput screening through enzyme/cell-based assays using small molecule libraries is essential

JOB DESCRIPTION

In this position you will support chemical biology efforts underpinning new lead discovery efforts by providing high throughput biology expertise including, but not limited to the following;

  • Proficient in biochemistry, enzymology, assay development, lab automation and HTS

  • High throughput screening assays and application of various in vitro techniques

  • Specific experience with biochemical and cell based assays applying luminescence, fluorescence, TR-FRET, FP and alpha screen assays

  • HTS sample processing, data generation, data interpretation and data reporting

  • Assist in maintenance of HTS compound/sample libraries, laboratory administrative requirements and maintenance of good laboratory practices in work environment

ESSENTIAL DUTIES AND JOB FUNCTIONS

  • Understanding of modern high throughput screening assay technologies

  • Experience in using laboratory automation equipment

  • Computer skills with extensive experience in data management, data analysis and statistical analysis

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

SENIOR SCIENTIST –Cell Molecular Biologist/Assay Development

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • PhD in Molecular Biology/Cell Biology/Biochemistry or other relevant fields

  • 2-4 yrs of postdoctoral/industry experience in cell-based assay development, immunocytochemistry/high-content imaging

  • Experience in basic biochemistry techniques like immunoprecipitations, pull down assays, Western blotting etc. is required

  • Knowledge in basic Molecular biology techniques like transformations, cloning, site-directed mutagenesis and stable cell line generation would be desirable

  • Self-motivated candidates who can drive research projects and should manage junior scientists with the capability to design, develop and troubleshoot experiments

  • Excellent communication and presentation skills

  • Must be detail oriented, organized with ability to analyze and communicate data effectively

  • Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment, meeting timelines

  • Good understanding of cell signaling pathways, disease biology having therapeutic implications would be required

JOB DESCRIPTION

  • In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;

  • Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs

  • Collaborate with project teams like high throughput screening, computational biology, medicinal chemistry and protein biology to develop lead molecules

  • Plan experiments, order reagents, set up assay platforms and deliver data in a timely fashion

  • Regular data analysis, project updates, literature survey and presentations

  • Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

  • Specific experience with cell biology and assay development using luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies

  • Ability to work on the bench implementing state-of-the-art technologies for the different assay platforms

  • Capability to perform basic biochemistry and molecular biology techniques

  • Excellent in data analysis, interpretation and communication

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

  • Managerial experience of junior scientists

ASSOCIATE RESEARCH SCIENTIST: Cell Molecular Biologist/Assay Development

KNOWLEDGE, EXPERIENCE AND SKILLS:

 

  • Master's degree in the discipline of life sciences with 1-3 years of academic or industrial work experience

  • Substantial experience in cell based assay development, immunocytochemistry, biochemistry (immunoprecipitations, Western blotting etc.) and molecular biology techniques (transformation cloning, stable cell line generation etc.) would be preferred

  • Must be detail oriented, well organized with ability to analyze and communicate data effectively

  • Excellent teamwork required and to work in a fast-paced, multi-disciplinary environment meeting timelines

JOB DESCRIPTION

In this position you will support chemical biology efforts underpinning new lead discovery by providing cell biology expertise including, but not limited to the following;

  • Develop, optimize and validate cell-based assay platforms for the hit to lead identification of small molecules in our drug discovery programs

  • Collaborate with multidisciplinary project teams like high throughput screening, computational biology, medicinal chemistry and protein biology in the discovery and identification of small molecules

  • Plan experiments, order reagents and set up assay platforms and deliver them in a timely fashion

  • Regular data analysis, project updates, literature survey and presentations on the target

  • Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

  • Understanding of cell biology, molecular biology and assay technologies

  • Experience in using luminescence, fluorescence, TR-FRET, FP, fluorescent immunocytochemistry, high content analysis, automated microscopy, label-free and other in vitro detection technologies

  • Computer skills with experience in data analysis

  • Must be detail oriented, well organized, and have strong communication skills

  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment

SENIOR SCIENTIST- Computational chemistry

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • PhD in chemistry or computational chemistry or other relevant fields.

  • 2-4 yrs of postdoctoral/industry experience in the application of computational tools to facilitate the design and optimization of potent and selective small molecules against various targets.

  • Competence with structure-based and ligand-based design techniques like protein modelling, virtual screening, QSAR, molecular dynamics simulations with strong programming/scripting in Perl, python and R is required.

  • Experience in applying modelling packages such as CCG, Schrödinger, CCDC, OpenEye or Accelrys is required

  • Knowledge in data analysis and data pipelining tools like Knime is desirable.

  • Background in organic/medicinal chemistry with understanding of chemical building blocks and common linkers used in medicinal chemistry is essential

  • Must be detail oriented, well organized with ability to analyze and communicate data effectively

  • Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment

JOB DESCRIPTION

In this position you will drive lead discovery projects by proposing testable hypothesis using computational chemistry tools. You will have to perform the following

  • Tailor small molecule modelling strategies based on the available experimental data and direct assays to test predictions

  • Perform cheminformatics analysis, calculate molecular properties, cluster and perform varied similarity searches

  • Understand the effect of mutations in the pocket, determine selectivity determinants among closely related protein family members

  • Employ ligand-based and structure-based approaches for iterative improvement of compound potency and selectivity

  • Play a major role in lead identification, optimization, scaffold hopping and fragment linking

DUTIES AND JOB FUNCTIONS

  • Perform statistical analysis of screening results and build QSAR models.

  • Determine the binding mode of hits by generating interaction fingerprints, performing pharmacophore guided molecular docking and MD simulations.

  • Propose modifications that can exploit the unexplored interactions in pocket to improve potency and selectivity.

  • Propose new leads by virtual screening, scaffold hopping, fragment linking, ligand/pocket similarity searches, etc.

  • Present a rational and testable hypothesis

RESEARCH ASSOCIATE - Computational chemistry

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • Master's degree in the discipline of chemistry/pharmacology with 1-3 years of academic or industrial work experience in the application of computer-aided drug discovery tools in proposing practical hypotheses.

  • Competence with structure-based and ligand-based design techniques like protein modelling, virtual screening, QSAR, molecular dynamics simulations with strong programming/scripting in Perl, python and R is required.

  • Must be motivated, well organized with the ability to analyze and communicate data effectively

  • Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment

JOB DESCRIPTION

In this position you will drive lead discovery projects by proposing testable hypothesis using computational chemistry expertise.

  • Generate chemical databases, develop conformations, calculate molecular properties, cluster and perform varied similarity searches

  • Employ ligand-based and structure-based approaches for iterative improvement of compound potency and selectivity

  • Regular data analysis, project updates, literature survey and presentations on the target

  • Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

  • Generate chemical libraries, perform statistical analysis of screening results and build QSAR models.

  • Determine the binding mode of hits by, performing pharmacophore guided molecular docking and MD simulations.

  • Propose modifications that can exploit the unexplored interactions in pocket to improve potency and selectivity.

  • Apply virtual screening, scaffold hopping, fragment linking, ligand/pocket similarity searches, etc.

  • Present a rational and testable hypothesis

COMPUTATIONAL BIOLOGIST

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • Master's/Bachelor’s degree in computer science, computational biology, bioinformatics or related area and at least 1-2 years of professional programming experience.

  • Broad array of technical skills such as the knowledge of databases and search engines, statistical analysis tools and environments, visualization tools, and the ability to quickly create research-grade programs and scripts.

  • Experience performing statistical analysis on large data sets, including proficiency in programs such as R and Matlab

  • Experience in developing bioinformatics applications using programming languages like Java, Python and Perl; knowledge of SQL and relational databases like Oracle, MySQL, SQL Server

  • Ability to administer and manage various operating systems like MacOSX, Windows and Linux

  • Experience using Apache, HTML, CSS, CGI, BioPerl, BioPython

JOB DESCRIPTION

In this position you will support drug discovery effort by providing computational biology expertise including but no limited to the following;

  • Monitoring project status, identifying and resolving problems which may impact the project results

  • Maintaining research software and hardware

  • Develop and implement data management policies

  • Scientific application alternatives, security, software usage, capacity planning, training, data recovery and backup procedures

  • Individual should be able to seamlessly interface biology with computational skills and develop new tools and methods

Essential Duties and Job Functions

  • Provide centralized in-house facilities for bioinformatics requirement of CCBT in liaison with central IT department at NCBS.

  • Management of databases, Laboratory Information Management System (LIMS), scientific software,

  • Augmentation of software and scientific tools used in drug discovery processes

  • Computer skills with experience in data analysis including statistical analysis

  • Must be detail oriented, well organized, and have strong communication skills


  • Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment


SENIOR SCIENTIST: STRUCTURAL BIOLOGY

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • PhD in Structural Biology or Biochemistry or other relevant fields.

  • 2-4 yrs of postdoctoral/industry experience in the application of structural biology/protein chemistry set up

  • Hands on experience in cloning, recombinant protein expression and purification

  • Expertise in solving protein structure by crystallization, X-ray diffraction and related tools.

  • Working knowledge of instruments such as protein fermenter, FPLC, circular dichroism, isothermal calorimetry, dynamic light scattering, Surface Plasmon resonance etc

  • Must be detail oriented, well organized with ability to analyze and communicate data effectively

  • Excellent teamwork is required to work in a fast-paced, multi-disciplinary environment

JOB DESCRIPTION

In this position you will coordinate with cell biologists, computational and medicinal chemists to understand the molecular nature of the protein-ligand and protein-drug interaction.

  • Oversee and coordinate cloning, protein expression and purification

  • Coordinate cross-departmental activities for the effective use of purified proteins

  • Biophysical characterization of protein-ligand and protein-small molecule interaction

  • Support and enable reproducible large-scale protein purifications in quantity and quality suitable for X-ray crystallography

  • Regular data analysis, project updates, literature survey and presentations on the target

  • Participate in project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS

The successful candidates will work in the area of protein science and structural biology, which include design, express, and purify proteins, and elucidate protein-protein interactions. Primary responsibilities include:

  • Support protein design, expression and purification to support small-molecule discovery

  • Biophysical characterization of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies (e.g. ITC, AUC, DSC, fluorescence)

  • Design of protein constructs for SBDD and protein sciences experiments

  • Integrating structural biology expertise into cross-functional project teams


  • Lead determination of high quality protein structures and co-crystal structures through crystallization, data collection and refinement

  • Communicating effectively with medicinal and computational chemists to translate hit to leads


HOW TO APPLY:
Interested candidates may send in the following information by email to This email address is being protected from spambots. You need JavaScript enabled to view it. .

  • Curriculum Vitae (CV)

  • Publication list

  • Contact details of three professional referees.

NO PAPER APPLICATIONS will be accepted.

Applications received upto 29th April 2014 will be considered in the first lot and thereafter reviewed periodically and screening/ selection taken up as appropriate.

inStem reserves the right to fill or not to fill the posts advertised.

Dean, inStem

Advt No.2/2014

Institute for Stem Cell Biology and Regenerative Medicine (http://www.instem.res.in/) is set in the beautiful GKVK campus adjacent to the National Center for Biological Sciences (http://www.ncbs.res.in/) in North Bangalore. It is part of the Bangalore biocluster consisting of NCBS and the Center for Cellular and Molecular Platforms (http://www.ccamp.res.in/). The three institutions work synergistically and leverage each other’s strengths for the success of all.

The Institute envisages team-driven interdisciplinary programmes in the areas of (a) Cardiac Biology, (b) Brain Development and repair, (c) Chemical Biology and Therapeutics, (d) Epithelial Biology, (e) Pluripotency and basic biology, and (e) Technology for advancement of Science. The Institute also has its Translational Unit at Christian Medical College Vellore, known as the Centre for Stem Cell Research.

inStem is looking to hire a Dean at the level of Senior Professor. The incumbent should be a mid–career or senior scientist who will provide leadership in the growth of the Institute. The person should have an outstanding track record of publications and could see their scientific career growing at inStem’s collaborative research environment.

Job Profile: The Dean will work very closely with the entire Faculty under the overall mandate of the Director and a Governing Council. The Dean shall co-ordinate all team driven programmes (existing and new) manage all academic activities – courses, evaluation of students, other researchers, and will drive the initiation of new programs. As the academic head of the Institute, the Dean will work with the Director in raising and managing resources required to carry out the mandate of the institute.

Nature of Appointment: On Five (5) year contract of which the First (1st) year shall be on probation. Renewal and long term appointment thereafter subject to review of performance.

How to Apply: Applications from and nominations of scientists are welcome. Applications should contain a brief (2-5 pages) description of ongoing and planned research directions, the institution building roles envisaged, a detailed curriculum-vitae and names of 5-8 referees (with e-mail address and mobile/telephone numbers) who can be contacted. Nominations of suitable candidates are particularly welcome.

Compensation: The compensation will be in the pay scale of HAG Rs.67,000-79,000.

Age limit: Below 55 (Fifty Five) years.

Applications/nominations may be sent by e-mail to : This email address is being protected from spambots. You need JavaScript enabled to view it.

The last date of receipt of application is May 20, 2014.

inStem reserves the right to fill or not to fill the post advertised. Only candidates called for interview will be informed of the result and no interim correspondence shall be entertained.

Corrigendum advertised through newspapers, Current Science and Employment News in order to effect the changes in the age limit, and extending the last date for receipt of applications.

 

 

Postdoctoral Position in Shravanti's lab

We are seeking highly motivated postdoctoral fellows interested in the area of epigenetics and human stem cell biology. Available projects involve deciphering the role of chromatin modulators in lineage specification (hematopoietic and neural lineages)using human pluripotent cells, as well as the application of functional genomic approaches to our areas of interest.


Candidates must have a Ph.D. and/or M.D. with prior experience in ES/iPSC culturing, differentiation flow-cytometry and microscopy techniques are encouraged to apply.

If interested, please send a CV, a brief statement detailing your reasons for interest in the position and your career goals, and contact information for references to at shravantidr AT instem dot res dot in

 

 

Senior Scientists - Centre for Chemical Biology and Therapeutics

Advertisement No.2/2013
Applications are invited from creative, self-motivated and experienced SENIOR SCIENTISTS with a track record of excellence at the forefront of drug discovery research in academia or industry for the position of ‘Staff Scientist’ in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research programme in a new initiative for chemical biology and therapeutics research.

The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, between the National Centre for Biological Sciences (NCBS) and the Institute for Stem Cell Biology and Regenerative Medicine (inStem). (http://instem.res.in/research/research-themes/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem/NCBS) coordinates the programme.

The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia. Thus, we are looking to recruit senior scientists with relevant postdoctoral experience of directing lead generation and target validation projects in a multidisciplinary team environment using functional reporting. A high level of expertise in any one of the following broad areas - molecular cell biology and/or protein biochemistry and structural biology and/or computational or synthetic chemistry - is required, along with sufficient familiarity of the other disciplines to permit the applicant to lead a multidisciplinary project. Applicants with experience in industry or in academic drug discovery programmes are particularly welcome.

Candidates must have a Ph.D. in a relevant subject, and several years’ relevant postdoctoral experience, ideally gained in pharma or biotech. A track record of accomplishment in drug discovery, ideally using structure-guided approaches, is essential, as is experienced in project management. Evidence of working with a high level of independence to deliver scientific projects ‘on time and to budget’ would be an advantage.

Job responsibilities

  • Manage projects aimed at developing new chemical entities that regulate intracellular signalling pathways disrupted in diseases like cancer, with a view to target validation and lead generation, in a multidisciplinary team environment using functional reporting.
  • Provide a high level of scientific expertise in one or more of the following areas: molecular cell biology of intracellular signaling; protein biochemistry/biophysics and structural biology; computational or synthetic chemistry.
  • Continuously monitor the progress of projects and revise strategy based on latest scientific findings, ideas and methodologies for discovery research.
  • Interpret and analyse scientific data and present the findings in internal and external scientific meetings.
  • Interact with academic researchers to develop new methods or insights relevant to project development.
  • Communicate with various stakeholders and coordinate research efforts between various academic groups, advisors and CROs.

Qualifications and experience

  • Strong academic qualifications, including: Ph.D. in a relevant subject, and several years’ relevant postdoctoral experience. Publications in high impact peer reviewed journals.
  • Wide ranging experience with drug discovery and development, gained in academia or pharma/biotech, preferably using structure-guided approaches.
  • A track record of accomplishment in drug discovery, preferably using structure-guided approaches, preferably in one or more of the following areas: target validation, lead generation or preclinical proof-of-concept.
  • High-level expertise in one or more of the following areas - molecular cell biology of intracellular signaling; protein biochemistry/biophysics and structural biology; computational or synthetic chemistry – and sufficient working familiarity with the other areas to manage multidisciplinary projects.
  • Experience of working with multidisciplinary teams of cell biologists, chemists, biophysicists and structural biologists for target validation, screening, and chemical lead optimization.
  • Experience in project management with evidence of working with a high level of independence to deliver scientific projects on time and to budget.

Application procedure:
An application package consisting of the following information should be sent by email to: This email address is being protected from spambots. You need JavaScript enabled to view it. and by hard copy to the Officer on Special Duty,Institute for Stem Cell Biology and Regenerative Medicine, NCBS-TIFR, GKVK PO, Bellary Road, Bangalore- 560065, on or before 2.12.2013.

  • Letter of intent
  • CV
  • Publication list
  • Contact details of three professional referees

General:

  1. Age will not be bar for candidates with exceptional experience in the specific field or for outstanding young Ph.Ds.
  2. Salary and benefits will be attractive and will be tailored according to the candidates experience and suitability for the project.
  3. This position is available for 3 years in the first instance with the possibility of renewal.

 

JRF position in Gulyani Lab - building new fluorescent-based biosensors for live cell imaging

We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. This would be a perfect opportunity for EITHER biology graduates who have an interest in building fluorescent biosensors and imaging OR chemistry graduates who are interested in various chemical biology and protein engineering approaches for biosensing. Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will also be opportunities to collaborate with other outstanding groups at inStem and NCBS in epithelial and adhesion biology, technology development and stem cell biology.

Desirable qualifications:
We are looking for

  1. Biology and biochemistry graduates with interest in imaging and quantitative biology; OR
  2. Chemistry graduates who have some chemical biology experience or inclinations; OR
  3. Physics or engineering graduates who have experience in fluorescence microscopy would also be welcome.

We are a new lab and are looking for people who are very motivated and want to have fun looking to find new ways of doing biology. Kindly apply with CV and full contact details of two referees to akashg at instem dot res dot in

 

Postdoctoral position in Gulyani laboratory - Chemical Biology and Fluorescence imaging

We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. We will also be building new biosensors for addressing signaling dynamics in stem cells in collaboration with other groups at inStem. We are looking for outstanding chemists who have a flair for adapting cutting edge chemical approaches for cell biology. Experience in dye chemistry, fluorescence spectroscopy and chemical biology will be highly desirable. Interest in quantitative approaches and fluorescence microscopy will be a plus.
Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will be ample opportunities to collaborate with other groups at inStem and NCBS for both technology/tool development as well to address fundamental questions in stem cell biology.

Kindly apply with CV and full contact details to akashg at instem dot res dot in.

 

Other Staff Positions

Academic Office Manager

Academic Office Manager

The Bangalore Biocluster, an innovative institutional model for cutting-edge scientific research and technology development in India, invites applications from suitable individuals for the position of Academic Office Manager.

The Bangalore Biocluster comprises of NCBS (www.ncbs.res.in), a premier centre for research and teaching in frontier areas of biology, inStem (http://instem.res.in/), an institute with a research focus on the broad area of stem cell and regenerative and CCAMP (http://www.ccamp.res.in/), created for enabling research and entrepreneurship at the Biocluster and beyond. It is envisioned that synergistic associations at the Biocluster will have a far greater impact on life sciences research than the sum of individual contributions from each member institution.

The Biocluster has a common Academic office serving the academic requirements of Faculty at both NCBS and inStem. The Academic Office Manager will work within this Office to help to oversee a range of activities, on behalf of Head Academics. The activities of the Academic Office Manager will help with oversight of the functioning of the academic office in close coordination with other sections in the Institutes. The role will require interfacing with faculty, administrative support and a range of external parties to drive forward the various academic programmes on the campus. The Academic office manager will be a key point of contact for students and researchers for advice on various academic policies of the organization.

Key responsibilities of the Academic Office Manager will include:

  • Graduate programme: orientation programmes, overseeing examinations and other modes of assessment for students on the graduate programme, organizing the Admissions Brochure and Handbooks, organising schedules for regular reviews of student research
  • Internship programmes with International and National Partners, involving interactions with universities, research institutions, funding agencies and faculty for processing applications and placements of students; overseeing travel details and stay for the students. 
  • Managing all aspects of selection and award of the the postdoctoral programmes including  competitive programmes offered on the campus, some in partnership with overseas Institutes. The person will aid in setting up engagements with international institutions for joint post doctoral Fellows Programmes and coordinate the management and assessments related to the Programme
  • Assisting with the organization and planning of specialist schools and courses offered by the faculty.
  • Manage a network of past and present members of student and postdoc bodies

The above job description is not exhaustive but indicative. S/he is expected to work in close coordination with and report to Head Academics.

Applicants to the role must have:

  • A PhD or other academic experience with a basic grasp of a wide range of research areas
  • Proven communication skills
  • Prior administrative work experience
  • Strong time-management and interpersonal skills
  • Initiative, enthusiasm and a flexible approach to work
  • The ability to analyze, summarize and communicate information
  • The ability to work both independently and as part of a team

Additional relevant experience (desirable):

  • Prior experience managing events and organising course and workshops
  • Prior experience with academic activities
  • Familiarity with online productivity tools

Closing date: 7 November 2014 (Only candidates shortlisted for interview will receive a response)

Application procedure:

An application package consisting of the following information should be sent by email to This email address is being protected from spambots. You need JavaScript enabled to view it. and by hard copy to the Head, RDO by a deadline of 7 November 2014. Incomplete applications will not be considered.

  • Up-to-date CV highlighting previous relevant experience with names and contact details of two referees
  • A one-page description (~500 words) of why you believe you are an appropriate candidate for the role

Development Officer

Development Officer

The Bangalore Biocluster, an innovative institutional model for cutting-edge scientific research and technology development in India, invites applications from suitable individuals for the position of DevelopmentOfficer.  

The Bangalore Biocluster comprises of NCBS (www.ncbs.res.in), a premier centre for research and teaching in frontier areas of biology, inStem (http://instem.res.in/), an institute with a research focus on the broad area of stem cell and regenerative and CCAMP (http://www.ccamp.res.in/), created for enabling research and entrepreneurship at the Biocluster and beyond. It is envisioned that synergistic associations at the Biocluster will have a far greater impact on life sciences research than the sum of individual contributions from each member institution.

The DevelopmentOfficer will work within the Research Development Office to help to create and manage a portfolio of charitable donations to the Biocluster. The activities of the DevelopmentOfficer will help to scale up and sustain charitable donations to the campus.

Key duties of the DevelopmentOfficer will include:

  • Working with RDO staff and other campus colleagues to identify institutional priorities requiring charitable funding
  • Working with RDO staff and other campus colleagues to develop strategies for identifying donors for the Biocluster
  • Identifying potential charitable donors for the campus
  • Cultivating relationships with future prospects and organisations
  • Helping to design fundraising pitches to a range of charitable donors
  • Relationship management with donors
  • Coordinating specific fundraising campaigns for the BioCluster
  • Working with the communications officer over PR work relating to donors
  • Creating and managing a dedicated webpage for fundraising activities
  • Contributing to other work within the team as needed

Applicants to the role should have:

  • A Phd in Life Sciences with a basic grasp of a wide range of biology research areas
  • Proven written, oral and visual communication skills
  • Experience of report writing
  • Excellent background research skills
  • Prior administrative work experience
  • Strong time-management and interpersonal skills
  • Initiative, enthusiasm and a flexible approach to work
  • The ability to analyze, summarize and communicate information
  • The ability to work both independently and as part of a team

Additional relevant experience (desirable):

  • Prior experience of fundraising
  • Experience of working in a multicultural environment
  • Prior event management experience
  • Experience in graphics and video editing

Closing date: 7 November 2014 (Only candidates shortlisted for interview will receive a response)

Application procedure:

An application package consisting of the following information should be sent by email to This email address is being protected from spambots. You need JavaScript enabled to view it. and by hard copy to the Head, RDO by a deadline of 7 November 2014. Incomplete applications will not be considered.

  • Up-to-date CV highlighting relevant experience with names and contact details of two referees
  • A one-page description of why you believe you are an appropriate candidate for the role
  • A PDF version of a 10-slide fundraising pitch for any research area on the Biocluster campus

Dean’s Office Manager

Dean’s Office Manager

The Bangalore Biocluster, an innovative institutional model for cutting-edge scientific research and technology development in India, invites applications from suitable individuals for the position of Dean’s Office Manager.

The Bangalore Biocluster comprises of NCBS (www.ncbs.res.in), a premier centre for research and teaching in frontier areas of biology, inStem (http://instem.res.in/), an institute with a research focus on the broad area of stem cell and regenerative and CCAMP (http://www.ccamp.res.in/), created for enabling research and entrepreneurship at the Biocluster and beyond. It is envisioned that synergistic associations at the Biocluster will have a far greater impact on life sciences research than the sum of individual contributions from each member institution.  The Biocluster has a common Dean’s office serving the academic requirements of Faculty at both NCBS and inStem. The Dean’s Office Manager will work within this Office, interacting with campus administrative support services as required, to coordinate activities on behalf of the Deans.

Key duties of the Dean’s Office Manager will include:

  • Oversight of faculty applications, including all aspects related to the operations and management of the web portal, interacting with administrative services as required. 
  • Overseeing the faculty review process 
  • Managing institutional review processes: Governing Council, Scientific Advisory Boards, Specialist visitors, Annual Reviews etc in . 
  • Statutory Committees: setting institution calendars, coordination with internal and external parties, minutes, reporting  and coordination with funding agencies if needed. 
  • Drafting and administration of MoUs coordinating with concerned offices and sections as needed. 
  • Coordinating Institutional visits by Scientific Visitors and Advisors working across different sections as needed
  • Aid in setting up engagements with international visiting scientist for annual assessment, facilitate connections among researchers and bring scientists together to nurture new collaborations, organize committee meetings from time to time and develop a methodology to maintain reports of critical meetings
  • Coordination of the Faculty Handbook

Applicants to the role must have:

  •  A PhD or other academic experience with a basic grasp of a wide range of research areas
  • Prior relevant administrative work experience
  • Experience of report writing
  • Strong time-management and interpersonal skills
  • Initiative, enthusiasm and a flexible approach to work
  • The ability to analyze, summarize and communicate information
  • The ability to work both independently and as part of a team

Additional relevant experience (desirable):

  • Prior experience in managing people
  • Prior experience in academic settings
  • Familiarity with online productivity tools
  • Prior experience working with online databases
  • Experience of working in a multicultural environment
  • Prior experience drafting and finalising agreements

Closing date: 7 November 2014 (Only candidates shortlisted for interview will receive a response)

Application procedure:

An application package consisting of the following information should be sent by email to This email address is being protected from spambots. You need JavaScript enabled to view it. and by hard copy to the Head, RDO by a deadline of 7 November 2014. Incomplete applications will not be considered.

  • Up-to-date CV highlighting previous relevant experience with names and contact details of two referees
  • A one-page description (~500 words) of why you believe you are an appropriate candidate for the role

Reach Us

Institute for Stem Cell Biology and Regenerative Medicine,
National Centre for Biological Sciences,
Tata Institute of Fundamental Research,
GKVK, Bellary Road,
Bangalore 560065, India.

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