Up to 3 years funding is available for a JRF/SRF to work on an exciting collaborative project between InStem in Bangalore, India, and UPMC in Paris, France.
The Dhawan lab uses a broad-based collaborative effort, analysing pluripotent, multipotent and monopotent stem cells to uncover common and distinct epigenetic pathways governing potency or ‘stemness’. As a result the successful applicant will be exposed to a wide spectrum of scientific approaches and have the opportunity to interact with experts in many different areas of research.
The applicant will be based in InStem, a highly collaborative and intellectually stimulating environment that provides world-class facilities. InStem shares the campus and has extensive collaborations with NCBS, a premier research institute in India, and C-CAMP, a new research institute that provides high-end platform services.
The work involves a broad range of scientific techniques including; tissue culture (primary cells and cell lines), mouse models, over/under-expression studies, ChIP/chromatin studies, microscopy, flow cytometry, Mass-spec, protein expression and purification, in addition to standard molecular biology and biochemistry techniques.
Required Qualification: Candidates should possess an M.Sc. or equivalent degree in life sciences.
Any additional work experience in any/all of the above mentioned areas is a plus.
Applications are invited from creative, self-motivated and experienced SENIOR SCIENTISTS with a track record of excellence at the forefront of drug discovery research in academia or industry for the position of ‘Staff Scientist’ in The Centre for Chemical Biology and Therapeutics (CCBT). The successful candidate will participate in a multidisciplinary research programme in a new initiative for chemical biology and therapeutics research.
The Centre for Chemical Biology and Therapeutics (CCBT) is an inter-institutional collaboration funded by the Department of Biotechnology, Government of India, between the National Centre for Biological Sciences (NCBS) and the Institute for Stem Cell Biology and Regenerative Medicine (inStem). (http://instem.res.in/research/research-themes/center-for-chemical-biology-and-therapeutics). It is an integrated multidisciplinary research centre designed to pioneer new approaches to create small-molecule tools that target intracellular signaling pathways for chemical biology and molecular therapeutics, and use them to conduct hypothesis-generating and hypothesis-driven translational research on systems of biomedical importance. Its overall vision will be to foster innovative therapeutic interventions for important human diseases. It is located on the NCBS campus in north Bangalore, a premier site for biomedical research equipped with the latest instrumentation and facilities, with a flourishing community of academic and industrial researchers. Professor Ashok Venkitaraman (University of Cambridge, UK, and inStem/NCBS) coordinates the programme.
The CCBT operates through the uniquely integrated effort of multidisciplinary project teams using common technological platforms, and not as a collection of independent PI-led labs that is usual in academia. Thus, we are looking to recruit senior scientists with relevant postdoctoral experience of directing lead generation and target validation projects in a multidisciplinary team environment using functional reporting. A high level of expertise in any one of the following broad areas - molecular cell biology and/or protein biochemistry and structural biology and/or computational or synthetic chemistry - is required, along with sufficient familiarity of the other disciplines to permit the applicant to lead a multidisciplinary project. Applicants with experience in industry or in academic drug discovery programmes are particularly welcome.
Candidates must have a Ph.D. in a relevant subject, and several years’ relevant postdoctoral experience, ideally gained in pharma or biotech. A track record of accomplishment in drug discovery, ideally using structure-guided approaches, is essential, as is experienced in project management. Evidence of working with a high level of independence to deliver scientific projects ‘on time and to budget’ would be an advantage.
Qualifications and experience
National Centre for Biological Sciences (www.ncbs.res.in), a premier centre for research and teaching in frontier areas of biology, invites applications from suitable individuals for the position of Program Manager, Academics.
The Program Manager, Academics will liaise with the academic office to ensure smooth functioning of the academic activities of the Bangalore Biocluster (NCBS, InStem and C-CAMP). The activities of the Program Manager, Academics will help to raise the profile of research and training conducted at NCBS both within the Indian and international scientific communities.
The job responsibilities include
An application package consisting of the following information should be sent by email to kripav at ncbs dot res dot in and by hard copy to the Research and Academic coordinator by July 31, 2103
InStem is highly collaborative and intellectually stimulating environment that provides world-class facilities. InStem shares the campus and has extensive collaborations with NCBS, a premier research institute in India. C-CAMP is a new research institute in the same campus, which also provides high-end platform services. Currently, InStem is expanding its post-doctoral program to bring bright young scientists into this vibrant atmosphere.
The lab works on two broad themes. One of the interests is to map the gene regulatory circuits controlling lineage-specification in early vertebrate mesoderm. Systematic genome –scale approaches such as ChIP-sequencing for key transcription factors in combination with mouse genetics studies will be carried out towards this goal. This study would also require bio-informatics expertise. Another major interest in the lab is in understanding vertebrate head evolution. Particularly, we aim to investigate the mechanistic basis for the emergence of novel embryonic cell types that are central to head evolution. Initially, this study would employ mouse genetic studies and possibly, a high-throughput RNAi screen to determine the regulatory network that underlie evolution of novel cell types. For more details, click here.
Candidates with experience / expertise in mouse genetics and / or ChIP-sequencing approaches will be favored.
Contact: Dr. Ramkumar Sambasivan – ramkumars at instem.res.in
We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. This would be a perfect opportunity for EITHER biology graduates who have an interest in building fluorescent biosensors and imaging OR chemistry graduates who are interested in various chemical biology and protein engineering approaches for biosensing. Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will also be opportunities to collaborate with other outstanding groups at inStem and NCBS in epithelial and adhesion biology, technology development and stem cell biology.
We are looking for
We are a new lab and are looking for people who are very motivated and want to have fun looking to find new ways of doing biology. Kindly apply with CV and full contact details of two referees to akashg at instem dot res dot in
We are setting up a composite program to build biosensors for imaging intracellular protein activation in living cells. The lab will be focused on technology development to build reporters for cell signaling as well as uncovering the basic mechanisms of signaling, especially in the context of cell adhesion and cell migration. We will also be building new biosensors for addressing signaling dynamics in stem cells in collaboration with other groups at inStem. We are looking for outstanding chemists who have a flair for adapting cutting edge chemical approaches for cell biology. Experience in dye chemistry, fluorescence spectroscopy and chemical biology will be highly desirable. Interest in quantitative approaches and fluorescence microscopy will be a plus.
Our approach is very interdisciplinary in nature and will employ diverse methods for probe development and solving outstanding problems in cell signaling. We are specifically interested in using high-throughput screening and high-content imaging to build suitable biosensors. There will be ample opportunities to collaborate with other groups at inStem and NCBS for both technology/tool development as well to address fundamental questions in stem cell biology.
Kindly apply with CV and full contact details to akashg at instem dot res dot in.
To design, establish and run a professionally managed animal facility with a team of experts working under the director.
To oversee multiple teams - transgenic, veterinarian, and colony maintenance.
To network and integrate with international animal facilities and experts for continuous growth of the facility to make the facility world class.
To implement a management plan that includes allocating space and best practice for animal welfare
To analyze requests for genetic manipulations for relevance and avoid redundancy
To establish/enforce policies for compliance with relevant oversight agencies to ensure program accreditation
Ph.D. Degree in relevant field
Managerial and team leadership experience, with animal facility supervisory work preferred
Extensive knowledge of transgenic/gene targeting technologies, ES isolation, culture and analysis, cryopreservation and recovery of embryos and sperm, molecular biology, and animal husbandry
Exceptional interpersonal skills
Prior international networking experience to establish collaborations and utilize existing consortia.
Detailed familiarity with animal welfare regulation
Applicants can be of any nationality
Languages: English both spoken and written is essential.
Tenure: This position is initially for three years, extendable to five based on requirements and performance. Subsequent terms will be for five years with annual reviews.
This package must include:
Up-to-date CV with names and contact details of three referees
Brief description of your skills that are relevant to the position of director
Applications will be accepted until the position is filled by a suitable candidate. Please note that only short listed candidates will be notified.
The Bangalore Biocluster, an innovative institutional model for cutting-edge scientific research and technology development in India, invites applications from suitable individuals for the position of External Liaison Officer.
The Bangalore Biocluster comprises of NCBS (www.ncbs.res.in), a premier centre for research and teaching in frontier areas of biology, inStem (http://instem.res.in/), a newly-established institute with a research focus on the broad area of stem cell and regenerative and CCAMP (http://www.ccamp.res.in/), created for enabling research and entrepreneurship at the Biocluster and beyond. It is envisioned that synergistic associations at the Biocluster will have a far greater impact on life sciences research than the sum of individual contributions from each member institution.
The External Liaison Officer will work in close association with the Research Development Office to provide a range of external liaison services on behalf of the research community at the Biocluster. The role will require both cohesive and independent representation of the member institutions of the Biocluster. The activities of the External Liaison Officer will help to raise the profile of research and training conducted at the Biocluster both within the Indian and international scientific communities.
Key duties of the External Liaison Officer will include:
Applicants to the role should have:
Closing date: 31 July 2013 (Only candidates shortlisted for interview will receive a response)
An application package consisting of the following information should be sent by email to rdoNCBS at gmail dot com and by hard copy to the Head, RDO by a deadline of 31 July 2013: